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From the following article:

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Jiwang Zhang, Justin C. Grindley, Tong Yin, Sachintha Jayasinghe, Xi C. He, Jason T. Ross, Jeffrey S. Haug, Dawn Rupp, Kimberly S. Porter-Westpfahl, Leanne M. Wiedemann, Hong Wu and Linheng Li

Nature 441, 518-522 (25 May 2006)

doi:10.1038/nature04747

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

PTEN governs the number and activation state of HSCs and PTEN expression is associated with cyclin D1.

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Figure 2

Deletion of PTEN results in HSC expansion and mobilization and impaired bone marrow lodging.

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Figure 3

Lineage analysis and competitive repopulation assay.

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Figure 4

Loss of PTEN results in myeloproliferative disorder (MPD) and leukaemia.

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