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Nature 441, 293-294 (18 May 2006) | doi:10.1038/441293a; Published online 17 May 2006
Microbiology: Antibiotic stops 'ping-pong' match
Eric D. Brown1
Abstract
As bacteria become resistant to existing drugs, there is a need for antibiotics with new modes of action. Such a compound has been found, and it works by binding to an intermediate in the catalytic cycle of its target.
Pathogenic bacteria have developed strains that are resistant to almost all antibiotics in use today. Particularly worrisome are infections by a large group of bacteria classified as being Gram-positive, such as staphylococci and enterococci, which cause pneumonia and other, often fatal, infections.
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