Figures and Tables
From the following article:
Critical role for the p110
phosphoinositide-3-OH kinase in growth and metabolic regulation
Lazaros C. Foukas, Marc Claret, Wayne Pearce, Klaus Okkenhaug, Stephen Meek, Emma Peskett, Sara Sancho, Andrew J. H. Smith, Dominic J. Withers & Bart Vanhaesebroeck
Nature 441, 366-370(18 May 2006)
doi:10.1038/nature04694
Figure 1
Mechanism of action of p110
D933A knockin strategy and effect on signalling and growth in p110D933A/D933A embryos and p110D933A/WT mice.
Figure 2
Hyperinsulinaemia, impaired glucose and insulin tolerance, increased food intake, increased adiposity and hyperleptinaemia in p110D933A/WT mice.
Figure 3
Normal proximal insulin receptor signalling events but impaired PI(3)K pathway activation in p110D933A/WT mice.
