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Nature 441, 32-34 (4 May 2006) | doi:10.1038/441032a; Published online 3 May 2006
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Paleobiologist / Biogeochemist
- University of Cincinnati
- Cincinnati, Ohio, USA
Postdoctoral Research Fellows
- Northwestern University
- Chicago, Illinois, United States
Cell biology: Divining cancer cell weaknesses
William G. Kaelin1
Abstract
Tumour cells tend to carry many gene mutations, but at a potential cost to their overall fitness. Studying the interactions between genes on a large scale could be a way of identifying the chinks in the tumour cell armour.
Cancer arises when the right combination of genes is mutated in a susceptible cell, much like lock tumblers falling into place. These mutations bestow various properties of malignancy upon the cell, such as independence from growth control and the ability to colonize other tissues.
- William G. Kaelin is at the Howard Hughes Medical Institute, Dana-Farber Cancer Institute, and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Email: William_Kaelin@dfci.harvard.edu
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