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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I

Christian G. Riedel, Vittorio L. Katis, Yuki Katou, Saori Mori, Takehiko Itoh, Wolfgang Helmhart, Marta Gálová, Mark Petronczki, Juraj Gregan, Bulent Cetin, Ingrid Mudrak, Egon Ogris, Karl Mechtler, Laurence Pelletier, Frank Buchholz, Katsuhiko Shirahige & Kim Nasmyth

Nature 441, 53-61(4 May 2006)

doi:10.1038/nature04664

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Sgo1 binds to PP2A-pi in vivo.

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Figure 2

PP2A-pi is required to protect centromeric sister chromatid cohesion at meiosis I in S. pombe.

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Figure 3

PP2A-pi prevents premature loss of centromeric sister chromatid cohesion at meiosis I in S. cerevisiae.

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Figure 4

PP2A-pi localizes to S. pombe centromeres in an SpSgo1-dependent manner.

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Figure 5

PP2A-pi is recruited to the centromeres in S. cerevisiae and mammalian cells.

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Figure 6

Artificial recruitment of PP2A-pi to chromosome arms in S. pombe prevents removal of arm cohesin, blocks nuclear divisions and causes dephosphorylation of SpRec8 during meiosis.

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