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Cell biology

Divining cancer cell weaknesses

Tumour cells tend to carry many gene mutations, but at a potential cost to their overall fitness. Studying the interactions between genes on a large scale could be a way of identifying the chinks in the tumour cell armour.

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Figure 1: Identifying shRNAs that impair cancer-cell fitness in a context-dependent manner.

References

  1. Ngo, V. N. et al. Nature 441, 106–110 (2006).

    Article  ADS  CAS  Google Scholar 

  2. Sharom, J. R., Bellows, D. S. & Tyers, M. Curr. Opin. Chem. Biol. 8, 81–90 (2004).

    Article  CAS  Google Scholar 

  3. Kaelin, W. G. Nature Rev. Cancer 5, 689–698 (2005).

    Article  CAS  Google Scholar 

  4. Hartwell, L., Szankasi, P., Roberts, C., Murray, A. & Friend, S. Science 278, 1064–1068 (1997).

    Article  ADS  CAS  Google Scholar 

  5. Willingham, A. T., Deveraux, Q. L., Hampton, G. M. & Aza-Blanc, P. Oncogene 23, 8392–8400 (2004).

    Article  CAS  Google Scholar 

  6. Shoemaker, D. D., Lashkari, D. A., Morris, D., Mittmann, M. & Davis, R. W. Nature Genet. 14, 450–456 (1996).

    Article  CAS  Google Scholar 

  7. Hensel, M. et al. Science 269, 400–403 (1995).

    Article  ADS  CAS  Google Scholar 

  8. Berns, K. et al. Nature 428, 431–437 (2004).

    Article  ADS  CAS  Google Scholar 

  9. Paddison, P. J. et al. Nature 428, 427–431 (2004).

    Article  ADS  CAS  Google Scholar 

  10. Lam, L. T. Clin. Cancer Res. 11, 28–40 (2005).

    Article  CAS  Google Scholar 

Download references

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Kaelin, W. Divining cancer cell weaknesses. Nature 441, 32–34 (2006). https://doi.org/10.1038/441032a

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