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Making collider endorsement count p1089

There is broad backing for a US bid to build the International Linear Collider.


Bioethics at the bench p1089

Bioethicists should be close — but not too close — to the lab action.


Machine readability p1090

A publishing initiative seems ready to make text mining simpler.



Research Highlights

Research highlights p1092




Shifting constant could shake laws of nature p1094

Proton–electron mass ratio may be on the move.

Mark Peplow


US particle physics fights for survival p1094

Americans urged to host International Linear Collider.

Geoff Brumfiel


Sidelines p1095


World Bank defends efforts to curb malaria p1096

Critics say funding promises have been broken.

Michael Hopkin


Last hope for river dolphins p1096

But preliminary survey fails to find any surviving 'baiji'.

Rex Dalton


Flu-vaccine makers toil to boost supply p1099

Stock shortfall highlights need for alternative strategy.

Carina Dennis


Feel it in your bones p1100

Deciding whether our ancestors evolved as a single lineage may depend more on philosophy than fossils. Rex Dalton reports.


News in brief p1102



News Features

Bioethics: Dial 'E' for ethics p1104

Facing a moral dilemma in the lab? No reason to panic. Helen Pilcher meets the academic troubleshooters who promise a quick answer to any ethical problem.


See also: Editor's summary

Archaeology: Digital digs p1106

Archaeologists are bringing past worlds vividly to life on the computer screen. But are the high-tech graphics helping science, or are they just pretty pictures? Michael Bawaya takes a look.


See also: Editor's summary

Geophysics: Magical mantle tour p1108

Geophysicists are racing to understand a recently discovered phenomenon deep in the Earth. David Cyranoski joins them.




Crunch time for New Jersey lab p1111

A global merger will put the long-suffering Bell Labs through the wringer yet again. But could joint ownership benefit the world-famous facility in the long run? Kurt Kleiner investigates.




Everyone listed on Dolly paper met established criteria for authorship p1112

Alan Colman


It's incredible how often we're surprised by findings p1112

Michal Jasienski


Funding should recognize outcome, not income p1112

Christopher Exley



Books and Arts

Where are the switches on this thing? p1113

Asking the big questions in neuroscience.

Kevan A. C. Martin reviews 23 Problems in Systems Neuroscience edited by J. Leo van Hemmen and Terrence J. Sejnowski


Seeking meaning in the void p1114

Simon Singh reviews The View from the Center of the Universe: Discovering Our Extraordinary Place in the Cosmos by Joel R. Primack and Nancy Ellen Abrams


Sympathy for the devil p1115

Matthew J. Phillips reviews Tasmanian Devil: A Unique and Threatened Animal by David Owen and David Pemberton



News and Views

Language: Startling starlings p1117

Recursion, once thought to be the unique province of human language, now seems to be within the ken of a common songbird — perhaps providing insight into the origins of language.

Gary F. Marcus


See also: Editor's summary

Superconductivity: Quantum stripe search p1118

Do quantum stripes exist or not? Further indirect evidence for this controversial behaviour of electrons in high-temperature superconductors comes from measurements of atomic-lattice vibrations.

Jan Zaanen


See also: Editor's summary

Biomaterials: Gripping stuff p1119

Rosamund Daw


Palaeoclimatology: The woods fill up with snow p1120

Palaeoclimatological evidence covering the past millennium suggests that the global water cycle has changed in the past century. Agreement with climate models points to human activity as the main cause.

Michael N. Evans


See also: Editor's summary

Molecular biology: Singled out for integration p1121

Bacteria regularly swap genes among themselves. The structure of an enzyme that mediates the spread of certain DNA elements reveals the unusual way in which they take up residence in new genomes.

Michael Chandler


See also: Editor's summary


Brief Communications

Gene therapy: Therapeutic gene causing lymphoma p1123

Insight into risks posed by corrective gene therapy comes from an immunodeficient mouse model.

Niels-Bjarne Woods, Virginie Bottero, Manfred Schmidt, Christof von Kalle and Inder M. Verma


See also: Editor's summary


Brief Communications Arising

Molecular virology: Was the 1918 pandemic caused by a bird flu? pE8

Mark J. Gibbs and Adrian J. Gibbs


See also: Editor's summary

Molecular virology: Was the 1918 flu avian in origin? pE9

Janis Antonovics, Michael E. Hood and Christi Howell Baker


Molecular virology: Was the 1918 pandemic caused by a bird flu? Was the 1918 flu avian in origin? (Reply) pE9

Jeffery K. Taubenberger, Ann H. Reid, Raina M. Lourens, Ruixue Wang, Guozhong Jin and Thomas G. Fanning



Insight: Early Universe

Insight: Early Universe

Early Universe p1125

Leslie Sage


Cosmology from start to finish p1126

Charles L. Bennett


Is our Universe natural? p1132

Sean M. Carroll


The large-scale structure of the Universe p1137

Volker Springel, Carlos S. Frenk and Simon D. M. White


High-redshift galaxy populations p1145

Esther M. Hu and Lennox L. Cowie


Heavy element synthesis in the oldest stars and the early Universe p1151

John J. Cowan and Christopher Sneden




Structural basis for broad DNA-specificity in integron recombination p1157

Douglas MacDonald, Gaëlle Demarre, Marie Bouvier, Didier Mazel and Deshmukh N. Gopaul


See also: Editor's summary | News and Views by Chandler



Origin of the obliquities of the giant planets in mutual interactions in the early Solar System p1163

Adrián Brunini


See also: Editor's summary

Wave and defect dynamics in nonlinear photonic quasicrystals p1166

Barak Freedman, Guy Bartal, Mordechai Segev, Ron Lifshitz, Demetrios N. Christodoulides and Jason W. Fleischer


Electron–phonon coupling reflecting dynamic charge inhomogeneity in copper oxide superconductors p1170

D. Reznik, L. Pintschovius, M. Ito, S. Iikubo, M. Sato, H. Goka, M. Fujita, K. Yamada, G. D. Gu and J. M. Tranquada


See also: Editor's summary | News and Views by Zaanen

Dislocation multi-junctions and strain hardening p1174

Vasily V. Bulatov, Luke L. Hsiung, Meijie Tang, Athanasios Arsenlis, Maria C. Bartelt, Wei Cai, Jeff N. Florando, Masato Hiratani, Moon Rhee, Gregg Hommes, Tim G. Pierce and Tomas Diaz de la Rubia


See also: Editor's summary

The twentieth century was the wettest period in northern Pakistan over the past millennium p1179

Kerstin S. Treydte, Gerhard H. Schleser, Gerhard Helle, David C. Frank, Matthias Winiger, Gerald H. Haug and Jan Esper


See also: Editor's summary | News and Views by Evans

Lamprey-like gills in a gnathostome-related Devonian jawless vertebrate p1183

Philippe Janvier, Sylvain Desbiens, Jason A. Willett and Marius Arsenault


See also: Editor's summary

Heterotrophic plasticity and resilience in bleached corals p1186

Andréa G. Grottoli, Lisa J. Rodrigues and James E. Palardy


See also: Editor's summary

Rank-related maternal effects of androgens on behaviour in wild spotted hyaenas p1190

S. M. Dloniak, J. A. French and K. E. Holekamp


See also: Editor's summary

The DNA sequence, annotation and analysis of human chromosome 3 p1194

Donna M. Muzny, Steven E. Scherer, Rajinder Kaul, Jing Wang, Jun Yu, Ralf Sudbrak, Christian J. Buhay, Rui Chen, Andrew Cree, Yan Ding, Shannon Dugan-Rocha, Rachel Gill, Preethi Gunaratne, R. Alan Harris, Alicia C. Hawes, Judith Hernandez, Anne V. Hodgson, Jennifer Hume, Andrew Jackson, Ziad Mohid Khan, Christie Kovar-Smith, Lora R. Lewis, Ryan J. Lozado, Michael L. Metzker, Aleksandar Milosavljevic, George R. Miner, Margaret B. Morgan, Lynne V. Nazareth, Graham Scott, Erica Sodergren, Xing-Zhi Song, David Steffen, Sharon Wei, David A. Wheeler, Mathew W. Wright, Kim C. Worley, Ye Yuan, Zhengdong Zhang, Charles Q. Adams, M. Ali Ansari-Lari, Mulu Ayele, Mary J. Brown, Guan Chen, Zhijian Chen, James Clendenning, Kerstin P. Clerc-Blankenburg, Runsheng Chen, Zhu Chen, Clay Davis, Oliver Delgado, Huyen H. Dinh, Wei Dong, Heather Draper, Stephen Ernst, Gang Fu, Manuel L. Gonzalez-Garay, Dawn K. Garcia, Will Gillett, Jun Gu, Bailin Hao, Eric Haugen, Paul Havlak, Xin He, Steffen Hennig, Songnian Hu, Wei Huang, Laronda R. Jackson, Leni S. Jacob, Susan H. Kelly, Michael Kube, Ruth Levy, Zhangwan Li, Bin Liu, Jing Liu, Wen Liu, Jing Lu, Manjula Maheshwari, Bao-Viet Nguyen, Geoffrey O. Okwuonu, Anthony Palmeiri, Shiran Pasternak, Lesette M. Perez, Karen A. Phelps, Farah J. H. Plopper, Boqin Qiang, Christopher Raymond, Ruben Rodriguez, Channakhone Saenphimmachak, Jireh Santibanez, Hua Shen, Yan Shen, Sandhya Subramanian, Paul E. Tabor, Daniel Verduzco, Lenee Waldron, Jian Wang, Jun Wang, Qiaoyan Wang, Gabrielle A. Williams, Gane K.-S. Wong, Zhijian Yao, JingKun Zhang, Xiuqing Zhang, Guoping Zhao, Jianling Zhou, Yang Zhou, further contributors, David Nelson, Hans Lehrach, Richard Reinhardt, Susan L. Naylor, Huanming Yang, Maynard Olson, George Weinstock and Richard A. Gibbs


Pluripotency of spermatogonial stem cells from adult mouse testis p1199

Kaomei Guan, Karim Nayernia, Lars S. Maier, Stefan Wagner, Ralf Dressel, Jae Ho Lee, Jessica Nolte, Frieder Wolf, Manyu Li, Wolfgang Engel and Gerd Hasenfuss


See also: Editor's summary

Recursive syntactic pattern learning by songbirds p1204

Timothy Q. Gentner, Kimberly M. Fenn, Daniel Margoliash and Howard C. Nusbaum


See also: Editor's summary | News and Views by Marcus

TMP21 is a presenilin complex component that modulates bold gamma-secretase but not alt epsilon-secretase activity p1208

Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt-Ulms, Toshitaka Kawarai, Christopher Bohm, Taiichi Katayama, Yongjun Gu, Nobuo Sanjo, Michael Glista, Ekaterina Rogaeva, Yosuke Wakutani, Raphaëlle Pardossi-Piquard, Xueying Ruan, Anurag Tandon, Frédéric Checler, Philippe Marambaud, Kirk Hansen, David Westaway, Peter St George-Hyslop and Paul Fraser


A voltage-gated proton-selective channel lacking the pore domain p1213

I. Scott Ramsey, Magdalene M. Moran, Jayhong A. Chong and David E. Clapham


Targeting C-reactive protein for the treatment of cardiovascular disease p1217

Mark B. Pepys, Gideon M. Hirschfield, Glenys A. Tennent, J. Ruth Gallimore, Melvyn C. Kahan, Vittorio Bellotti, Philip N. Hawkins, Rebecca M. Myers, Martin D. Smith, Alessandra Polara, Alexander J. A. Cobb, Steven V. Ley, J. Andrew Aquilina, Carol V. Robinson, Isam Sharif, Gillian A. Gray, Caroline A. Sabin, Michelle C. Jenvey, Simon E. Kolstoe, Darren Thompson and Stephen P. Wood


See also: Editor's summary

Lysyl oxidase is essential for hypoxia-induced metastasis p1222

Janine T. Erler, Kevin L. Bennewith, Monica Nicolau, Nadja Dornhöfer, Christina Kong, Quynh-Thu Le, Jen-Tsan Ashley Chi, Stefanie S. Jeffrey and Amato J. Giaccia


See also: Editor's summary

Detecting transient intermediates in macromolecular binding by paramagnetic NMR p1227

Junji Iwahara and G. Marius Clore



Technology Features

Gene expression: An expression of interest p1233

Understanding the regulation of gene expression in stem cells and neurons, and finding ways to manipulate it, are important challenges. Laura Bonetta searches out the tools for the job.

Laura Bonetta


Gene expression: Table of suppliers p1238





A howl of hope p1241

Comparing scientists to Beats.

Paul Smaglik


Career Views

Zachary Fisk, distinguished professor of physics, University of California, Irvine p1242

Physics leader follows in footsteps of giants.

Virginia Gewin


Thank you, Professor MacDonald p1242

Mentor's open door inspires trust.

Wyatt McMahon, Ebtesam Attaya, Toni Denison, Andrew Hockert & Ganesh Shankarling


The postdoc menu p1242

Picking from the postdoc menu.

Milan de Vries




Ringing up baby p1244

Order a little sister, then order her about.

Ellen Klages


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