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Editorials

Making collider endorsement count p1089

There is broad backing for a US bid to build the International Linear Collider.

doi:10.1038/4401089a


Bioethics at the bench p1089

Bioethicists should be close — but not too close — to the lab action.

doi:10.1038/4401090b


Machine readability p1090

A publishing initiative seems ready to make text mining simpler.

doi:10.1038/4401090a


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Research Highlights

Research highlights p1092

doi:10.1038/4401092a


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News

Shifting constant could shake laws of nature p1094

Proton–electron mass ratio may be on the move.

Mark Peplow

doi:10.1038/4401094a


US particle physics fights for survival p1094

Americans urged to host International Linear Collider.

Geoff Brumfiel

doi:10.1038/4401094b


Sidelines p1095

doi:10.1038/4401095a


World Bank defends efforts to curb malaria p1096

Critics say funding promises have been broken.

Michael Hopkin

doi:10.1038/4401096a


Last hope for river dolphins p1096

But preliminary survey fails to find any surviving 'baiji'.

Rex Dalton

doi:10.1038/4401096b


Flu-vaccine makers toil to boost supply p1099

Stock shortfall highlights need for alternative strategy.

Carina Dennis

doi:10.1038/4401099a


Feel it in your bones p1100

Deciding whether our ancestors evolved as a single lineage may depend more on philosophy than fossils. Rex Dalton reports.

doi:10.1038/4401100a


News in brief p1102

doi:10.1038/4401102a


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News Features

Bioethics: Dial 'E' for ethics p1104

Facing a moral dilemma in the lab? No reason to panic. Helen Pilcher meets the academic troubleshooters who promise a quick answer to any ethical problem.

doi:10.1038/4401104a

See also: Editor's summary


Archaeology: Digital digs p1106

Archaeologists are bringing past worlds vividly to life on the computer screen. But are the high-tech graphics helping science, or are they just pretty pictures? Michael Bawaya takes a look.

doi:10.1038/4401106a

See also: Editor's summary


Geophysics: Magical mantle tour p1108

Geophysicists are racing to understand a recently discovered phenomenon deep in the Earth. David Cyranoski joins them.

doi:10.1038/4401108a


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Business

Crunch time for New Jersey lab p1111

A global merger will put the long-suffering Bell Labs through the wringer yet again. But could joint ownership benefit the world-famous facility in the long run? Kurt Kleiner investigates.

doi:10.1038/4401111a


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Correspondence

Everyone listed on Dolly paper met established criteria for authorship p1112

Alan Colman

doi:10.1038/4401112a


It's incredible how often we're surprised by findings p1112

Michal Jasienski

doi:10.1038/4401112b


Funding should recognize outcome, not income p1112

Christopher Exley

doi:10.1038/4401112c


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Books and Arts

Where are the switches on this thing? p1113

Asking the big questions in neuroscience.

Kevan A. C. Martin reviews 23 Problems in Systems Neuroscience edited by J. Leo van Hemmen and Terrence J. Sejnowski

doi:10.1038/4401113a


Seeking meaning in the void p1114

Simon Singh reviews The View from the Center of the Universe: Discovering Our Extraordinary Place in the Cosmos by Joel R. Primack and Nancy Ellen Abrams

doi:10.1038/4401114a


Sympathy for the devil p1115

Matthew J. Phillips reviews Tasmanian Devil: A Unique and Threatened Animal by David Owen and David Pemberton

doi:10.1038/4401115a


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News and Views

Language: Startling starlings p1117

Recursion, once thought to be the unique province of human language, now seems to be within the ken of a common songbird — perhaps providing insight into the origins of language.

Gary F. Marcus

doi:10.1038/4401117a

See also: Editor's summary


Superconductivity: Quantum stripe search p1118

Do quantum stripes exist or not? Further indirect evidence for this controversial behaviour of electrons in high-temperature superconductors comes from measurements of atomic-lattice vibrations.

Jan Zaanen

doi:10.1038/4401118a

See also: Editor's summary


Biomaterials: Gripping stuff p1119

Rosamund Daw

doi:10.1038/4401119a


Palaeoclimatology: The woods fill up with snow p1120

Palaeoclimatological evidence covering the past millennium suggests that the global water cycle has changed in the past century. Agreement with climate models points to human activity as the main cause.

Michael N. Evans

doi:10.1038/4401120a

See also: Editor's summary


Molecular biology: Singled out for integration p1121

Bacteria regularly swap genes among themselves. The structure of an enzyme that mediates the spread of certain DNA elements reveals the unusual way in which they take up residence in new genomes.

Michael Chandler

doi:10.1038/4401121a

See also: Editor's summary


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Brief Communications

Gene therapy: Therapeutic gene causing lymphoma p1123

Insight into risks posed by corrective gene therapy comes from an immunodeficient mouse model.

Niels-Bjarne Woods, Virginie Bottero, Manfred Schmidt, Christof von Kalle and Inder M. Verma

doi:10.1038/4401123a

See also: Editor's summary


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Brief Communications Arising

Molecular virology: Was the 1918 pandemic caused by a bird flu? pE8

Mark J. Gibbs and Adrian J. Gibbs

doi:10.1038/nature04823

See also: Editor's summary


Molecular virology: Was the 1918 flu avian in origin? pE9

Janis Antonovics, Michael E. Hood and Christi Howell Baker

doi:10.1038/nature04824


Molecular virology: Was the 1918 pandemic caused by a bird flu? Was the 1918 flu avian in origin? (Reply) pE9

Jeffery K. Taubenberger, Ann H. Reid, Raina M. Lourens, Ruixue Wang, Guozhong Jin and Thomas G. Fanning

doi:10.1038/nature04825


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Insight: Early Universe


Insight: Early Universe

Early Universe p1125

Leslie Sage

doi:10.1038/4401125a


Cosmology from start to finish p1126

Charles L. Bennett

doi:10.1038/nature04803


Is our Universe natural? p1132

Sean M. Carroll

doi:10.1038/nature04804


The large-scale structure of the Universe p1137

Volker Springel, Carlos S. Frenk and Simon D. M. White

doi:10.1038/nature04805


High-redshift galaxy populations p1145

Esther M. Hu and Lennox L. Cowie

doi:10.1038/nature04806


Heavy element synthesis in the oldest stars and the early Universe p1151

John J. Cowan and Christopher Sneden

doi:10.1038/nature04807



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Article

Structural basis for broad DNA-specificity in integron recombination p1157

Douglas MacDonald, Gaëlle Demarre, Marie Bouvier, Didier Mazel and Deshmukh N. Gopaul

doi:10.1038/nature04643

See also: Editor's summary | News and Views by Chandler


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Letters

Origin of the obliquities of the giant planets in mutual interactions in the early Solar System p1163

Adrián Brunini

doi:10.1038/nature04577

See also: Editor's summary


Wave and defect dynamics in nonlinear photonic quasicrystals p1166

Barak Freedman, Guy Bartal, Mordechai Segev, Ron Lifshitz, Demetrios N. Christodoulides and Jason W. Fleischer

doi:10.1038/nature04722


Electron–phonon coupling reflecting dynamic charge inhomogeneity in copper oxide superconductors p1170

D. Reznik, L. Pintschovius, M. Ito, S. Iikubo, M. Sato, H. Goka, M. Fujita, K. Yamada, G. D. Gu and J. M. Tranquada

doi:10.1038/nature04704

See also: Editor's summary | News and Views by Zaanen


Dislocation multi-junctions and strain hardening p1174

Vasily V. Bulatov, Luke L. Hsiung, Meijie Tang, Athanasios Arsenlis, Maria C. Bartelt, Wei Cai, Jeff N. Florando, Masato Hiratani, Moon Rhee, Gregg Hommes, Tim G. Pierce and Tomas Diaz de la Rubia

doi:10.1038/nature04658

See also: Editor's summary


The twentieth century was the wettest period in northern Pakistan over the past millennium p1179

Kerstin S. Treydte, Gerhard H. Schleser, Gerhard Helle, David C. Frank, Matthias Winiger, Gerald H. Haug and Jan Esper

doi:10.1038/nature04743

See also: Editor's summary | News and Views by Evans


Lamprey-like gills in a gnathostome-related Devonian jawless vertebrate p1183

Philippe Janvier, Sylvain Desbiens, Jason A. Willett and Marius Arsenault

doi:10.1038/nature04471

See also: Editor's summary


Heterotrophic plasticity and resilience in bleached corals p1186

Andréa G. Grottoli, Lisa J. Rodrigues and James E. Palardy

doi:10.1038/nature04565

See also: Editor's summary


Rank-related maternal effects of androgens on behaviour in wild spotted hyaenas p1190

S. M. Dloniak, J. A. French and K. E. Holekamp

doi:10.1038/nature04540

See also: Editor's summary


The DNA sequence, annotation and analysis of human chromosome 3 p1194

Donna M. Muzny, Steven E. Scherer, Rajinder Kaul, Jing Wang, Jun Yu, Ralf Sudbrak, Christian J. Buhay, Rui Chen, Andrew Cree, Yan Ding, Shannon Dugan-Rocha, Rachel Gill, Preethi Gunaratne, R. Alan Harris, Alicia C. Hawes, Judith Hernandez, Anne V. Hodgson, Jennifer Hume, Andrew Jackson, Ziad Mohid Khan, Christie Kovar-Smith, Lora R. Lewis, Ryan J. Lozado, Michael L. Metzker, Aleksandar Milosavljevic, George R. Miner, Margaret B. Morgan, Lynne V. Nazareth, Graham Scott, Erica Sodergren, Xing-Zhi Song, David Steffen, Sharon Wei, David A. Wheeler, Mathew W. Wright, Kim C. Worley, Ye Yuan, Zhengdong Zhang, Charles Q. Adams, M. Ali Ansari-Lari, Mulu Ayele, Mary J. Brown, Guan Chen, Zhijian Chen, James Clendenning, Kerstin P. Clerc-Blankenburg, Runsheng Chen, Zhu Chen, Clay Davis, Oliver Delgado, Huyen H. Dinh, Wei Dong, Heather Draper, Stephen Ernst, Gang Fu, Manuel L. Gonzalez-Garay, Dawn K. Garcia, Will Gillett, Jun Gu, Bailin Hao, Eric Haugen, Paul Havlak, Xin He, Steffen Hennig, Songnian Hu, Wei Huang, Laronda R. Jackson, Leni S. Jacob, Susan H. Kelly, Michael Kube, Ruth Levy, Zhangwan Li, Bin Liu, Jing Liu, Wen Liu, Jing Lu, Manjula Maheshwari, Bao-Viet Nguyen, Geoffrey O. Okwuonu, Anthony Palmeiri, Shiran Pasternak, Lesette M. Perez, Karen A. Phelps, Farah J. H. Plopper, Boqin Qiang, Christopher Raymond, Ruben Rodriguez, Channakhone Saenphimmachak, Jireh Santibanez, Hua Shen, Yan Shen, Sandhya Subramanian, Paul E. Tabor, Daniel Verduzco, Lenee Waldron, Jian Wang, Jun Wang, Qiaoyan Wang, Gabrielle A. Williams, Gane K.-S. Wong, Zhijian Yao, JingKun Zhang, Xiuqing Zhang, Guoping Zhao, Jianling Zhou, Yang Zhou, further contributors, David Nelson, Hans Lehrach, Richard Reinhardt, Susan L. Naylor, Huanming Yang, Maynard Olson, George Weinstock and Richard A. Gibbs

doi:10.1038/nature04728


Pluripotency of spermatogonial stem cells from adult mouse testis p1199

Kaomei Guan, Karim Nayernia, Lars S. Maier, Stefan Wagner, Ralf Dressel, Jae Ho Lee, Jessica Nolte, Frieder Wolf, Manyu Li, Wolfgang Engel and Gerd Hasenfuss

doi:10.1038/nature04697

See also: Editor's summary


Recursive syntactic pattern learning by songbirds p1204

Timothy Q. Gentner, Kimberly M. Fenn, Daniel Margoliash and Howard C. Nusbaum

doi:10.1038/nature04675

See also: Editor's summary | News and Views by Marcus


TMP21 is a presenilin complex component that modulates bold gamma-secretase but not alt epsilon-secretase activity p1208

Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt-Ulms, Toshitaka Kawarai, Christopher Bohm, Taiichi Katayama, Yongjun Gu, Nobuo Sanjo, Michael Glista, Ekaterina Rogaeva, Yosuke Wakutani, Raphaëlle Pardossi-Piquard, Xueying Ruan, Anurag Tandon, Frédéric Checler, Philippe Marambaud, Kirk Hansen, David Westaway, Peter St George-Hyslop and Paul Fraser

doi:10.1038/nature04667


A voltage-gated proton-selective channel lacking the pore domain p1213

I. Scott Ramsey, Magdalene M. Moran, Jayhong A. Chong and David E. Clapham

doi:10.1038/nature04700


Targeting C-reactive protein for the treatment of cardiovascular disease p1217

Mark B. Pepys, Gideon M. Hirschfield, Glenys A. Tennent, J. Ruth Gallimore, Melvyn C. Kahan, Vittorio Bellotti, Philip N. Hawkins, Rebecca M. Myers, Martin D. Smith, Alessandra Polara, Alexander J. A. Cobb, Steven V. Ley, J. Andrew Aquilina, Carol V. Robinson, Isam Sharif, Gillian A. Gray, Caroline A. Sabin, Michelle C. Jenvey, Simon E. Kolstoe, Darren Thompson and Stephen P. Wood

doi:10.1038/nature04672

See also: Editor's summary


Lysyl oxidase is essential for hypoxia-induced metastasis p1222

Janine T. Erler, Kevin L. Bennewith, Monica Nicolau, Nadja Dornhöfer, Christina Kong, Quynh-Thu Le, Jen-Tsan Ashley Chi, Stefanie S. Jeffrey and Amato J. Giaccia

doi:10.1038/nature04695

See also: Editor's summary


Detecting transient intermediates in macromolecular binding by paramagnetic NMR p1227

Junji Iwahara and G. Marius Clore

doi:10.1038/nature04673


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Technology Features

Gene expression: An expression of interest p1233

Understanding the regulation of gene expression in stem cells and neurons, and finding ways to manipulate it, are important challenges. Laura Bonetta searches out the tools for the job.

Laura Bonetta

doi:10.1038/4401233a


Gene expression: Table of suppliers p1238

doi:10.1038/4401238a


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Naturejobs

Prospect

A howl of hope p1241

Comparing scientists to Beats.

Paul Smaglik

doi:10.1038/nj7088-1241a


Career Views

Zachary Fisk, distinguished professor of physics, University of California, Irvine p1242

Physics leader follows in footsteps of giants.

Virginia Gewin

doi:10.1038/nj7088-1242a


Thank you, Professor MacDonald p1242

Mentor's open door inspires trust.

Wyatt McMahon, Ebtesam Attaya, Toni Denison, Andrew Hockert & Ganesh Shankarling

doi:10.1038/nj7088-1242b


The postdoc menu p1242

Picking from the postdoc menu.

Milan de Vries

doi:10.1038/nj7088-1242c


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Futures

Ringing up baby p1244

Order a little sister, then order her about.

Ellen Klages

doi:10.1038/4401244a


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