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Nature 440, 1113-1114 (27 April 2006) | doi:10.1038/4401113a; Published online 26 April 2006

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Where are the switches on this thing?

Kevan A. C. Martin1

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Asking the big questions in neuroscience.

BOOK REVIEWED23 Problems in Systems Neuroscience

edited by J. Leo van Hemmen & Terrence J. Sejnowski

Oxford University Press: 2006. 530 pp. £49, $79.95

David Hilbert, in his opening address at the International Congress of Mathematicians in Paris in 1900, presented his colleagues with 23 problems whose investigation he thought would provide the major advances in mathematics in the twentieth century. Although about half of the problems remain unsolved, history shows that mathematicians rose splendidly to the challenge.

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