Supplementary information
From the following article:
Unique features of action potential initiation in cortical neurons
Björn Naundorf, Fred Wolf and Maxim Volgushev
Nature 440, 1060-1063(20 April 2006)
doi:10.1038/nature04610
Supplementary Methods and Supplementary Data
This file describes in detail all experimental and data analysis methods used in this study. This includes a description of the stationarity criteria for MP recordings and the estimation of AP (action potential) onset potentials and rapidness. We characterize our data sample and show that rapid AP onset, and substantial variability of AP onset potential are found in all cortical cell classes and argue that they are genuine characteristics of cortical neurons.
Supplementary Methods and Supplementary Data - Download PDF file (406KB)
Supplementary Notes 1
This file describes the Hodgkin–Huxley type conductance based models used in the study and the modifications which were applied to these models, such as changes of sodium channel activation curves and single channel stochasticity. We also describe parameter ranges explored. Finally, we show that rapidness and onset potential variability of AP initiation are strongly antagonistic in the whole class of Hodgkin–Huxley type conductance based models.
Supplementary Notes 2
This file introduces a model of AP initiation by cooperative activation of voltage-gated sodium channels and characterize its basic properties. Then we describe the computational consequences of the characteristic features of cortical action potential initiation. Using a novel phenomenological neuron model, we show that these features allow a neuronal population to encode rapidly varying signals and to suppress responses to slowly varying stimuli.
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