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Nature 440, 874-875 (13 April 2006) | doi:10.1038/440874a; Published online 12 April 2006
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Ageing: Chromatin unbound
Abstract
Sir2 proteins slow ageing in yeast by locking chromatin — the DNA and proteins in chromosomes — into a stable, silent state. Inactivating a Sir2 family protein in mice causes premature ageing and genome instability.
Genomes are exquisitely adapted to provide the information, at the right time and place, for cells to function. Loss of genome integrity has long been implicated in ageing: cancer, for example, occurs more frequently with age and can be caused by genome alterations.
- Jan Vijg is at the Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA.
Email: jvijg@buckinstitute.org. - Yousin Suh is in the Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, Texas 78245, USA.
Email: suhy@uthscsa.edu.
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