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Nature 440, 565-569 (15 January 2006) | doi:10.1038/nature04409;
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Gastroenterologist
- Wayne State University
- Detroit, Michigan, USA
Assistant Professor and Associate Professor
- Massachusetts General Hospital/ Harvard Medical School
- Charlestown, MA
The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
Chromosomes interact through their kinetochores with microtubule plus ends and they are segregated to the spindle poles as the kinetochore microtubules shorten during anaphase A of mitosis. The molecular natures and identities of coupling proteins that allow microtubule depolymerization to pull chromosomes to poles during anaphase have long remained elusive.
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