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Nature 440, 470-476 (23 March 2006) | doi:10.1038/nature04711; Published online 22 March 2006
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Review article KATP channels as molecular sensors of cellular metabolism
Colin G. Nichols1
Abstract
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of KATP has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.
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