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Nature 440, 427-429 (23 March 2006) | doi:10.1038/440427a; Published online 22 March 2006
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Professor of Cognitive Neuroscience
- Karolinska Institute
- Stockholm Sweden
University Full-Professor (W3, Tenure Track)
- University of Münster
- Munster 48149 Germany
Membrane biology: Permutations of permeability
William N. Zagotta1
Abstract
The first glimpse into the molecular basis of how sodium ions are transported across cell membranes by ion channels shows that cation-selective channels are variations on potassium channels.
Ion channels are nature's gatekeepers: by allowing certain ions to pass across the membrane and excluding others, these proteins control the electrical state of the cell. Channels selective for sodium ions allow Na+ to enter the cell, causing depolarization of the membrane.
- William N. Zagotta is in the Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195-7290, USA.
Email: zagotta@u.washington.edu
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