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Nature 440, 425-426 (23 March 2006) | doi:10.1038/440425a; Published online 22 March 2006

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Molecular biology: RNA lost in translation

David Tollervey1

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In any manufacturing process, quality control is crucial, and gene expression is no exception. A new pathway monitors mRNAs — the intermediaries of gene expression — and destroys faulty molecules.

For most human genes to be usefully expressed they must first be copied into messenger RNAs by the process of transcription. These then program large, RNA–protein complexes called ribosomes to synthesize a specific protein by 'translation'.

  1. David Tollervey is at the Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.
    Email: d.tollervey@ed.ac.uk

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