Access

News and Views

Nature 440, 425-426 (23 March 2006) | doi:10.1038/440425a; Published online 22 March 2006

Open Innovation Challenges

naturejobs

More science jobs
Post a job for free

Molecular biology: RNA lost in translation

David Tollervey1

Top

In any manufacturing process, quality control is crucial, and gene expression is no exception. A new pathway monitors mRNAs — the intermediaries of gene expression — and destroys faulty molecules.

For most human genes to be usefully expressed they must first be copied into messenger RNAs by the process of transcription. These then program large, RNA–protein complexes called ribosomes to synthesize a specific protein by 'translation'.

  1. David Tollervey is at the Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.
    Email: d.tollervey@ed.ac.uk

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

No mercy for messages that mess with the ribosome

Nature Structural & Molecular Biology News and Views (01 Apr 2006)

RESEARCH

Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation

Nature Letters to Editor (23 Mar 2006)

Translation of aberrant mRNAs lacking a termination codon or with a shortened 3′-UTR is repressed after initiation in yeast

The EMBO Journal Article (20 Apr 2005)

Translation of nonSTOP mRNA is repressed post-initiation in mammalian cells

The EMBO Journal Article (02 May 2007)

See all 7 matches for Research