Supplementary information

From the following article:

Sexual reproduction selects for robustness and negative epistasis in artificial gene networks

Ricardo B. R. Azevedo, Rolf Lohaus, Suraj Srinivasan, Kristen K. Dang and Christina L. Burch

Nature 440, 87-90(2 March 2006)

doi:10.1038/nature04488

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Supplementary Notes

This file was replaced on 5 October 2006. See Corrigendum to original paper.

This file contains Supplementary Methods, Supplementary Figures and their legends, and respective additional references. The Supplementary Methods contain a list of default network and population genetic parameters, methods for the experiments described in Fig. 3b (main text), details of the software used, and methods for the experiments reported in the Supplementary Figures. The Supplementary Figures show sensitivity analyses of the evolutionary responses in robustness and directional epistasis to changes in various network and population genetic parameters (Supplementary Figures 1, 4–9), estimates of the initial recombination load in the experiments described in Fig. 3b (main text) (Supplementary Figure 2), and the correlation between genetic robustness and directional epistasis in random networks (Supplementary Figure 3).

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