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Authors

Making the paper: Linda Perry pxiii

Plant fossils reveal ancient trade and agriculture in South America.

doi:10.1038/7080xiiia


Abstractions pxiii

doi:10.1038/7080xiiib


Quantified: Malta pxiii

doi:10.1038/7080xiiic


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Editorials

Everybody's fault p1

The Kashmiri earthquake highlights the urgent need for Pakistan and India to put aside their differences and build stronger scientific ties.

doi:10.1038/440001a


Evaluate this p1

The objective evaluation of research isn't working as it should.

doi:10.1038/440001b


Gradual force p2

A delicate probe, twenty years old this week, has transformed our understanding of the nanoscale.

doi:10.1038/440002a


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Research Highlights

Research highlights p4

doi:10.1038/440004a


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News

Disease surveillance needs a revolution p6

Bird flu has highlighted serious deficiencies in epidemiology.

Declan Butler

doi:10.1038/440006a


Physicists told to confront those big questions p7

Foundation hunts for far-out research proposals.

Geoff Brumfiel

doi:10.1038/440007a


Bets are placed for next Harvard president p8

Researchers hope Summers's successor will share passion for science.

Helen Pearson

doi:10.1038/440008a


Scepticism greets EU plan for virtual institute p8

Boosting innovation will take serious cash, say critics.

Quirin Schiermeier

doi:10.1038/440008b


Rules tighten for stem-cell studies p9

International group aims to make research collaborations simpler

Jim Giles

doi:10.1038/440009a


Demo backs animal lab in Oxford p10

Proponents of animal testing out in force for first time at rally

Michael Hopkin

doi:10.1038/440010a


Sackings put editorial freedom on the spot p10

Owners of medical journal deny editors fired for political reasons.

Emma Marris

doi:10.1038/440010b


Sidelines p11

doi:10.1038/440011a


Alternative energy plan criticized p12

Analysts say US research push is not enough.

Jacqueline Ruttiman and Emma Marris

doi:10.1038/440012a


News in brief p13

doi:10.1038/440013a


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News Features

Molecular microscopy: Focus on the living p14

Atomic force microscopes have revolutionized the study of materials, but probing watery biological systems has proved more difficult. Jenny Hogan asks whether a fix is at hand.

Jenny Hogan

doi:10.1038/440014a


Seismology: Shaking the foundations p16

Last autumn's deadly earthquake caught Pakistan's government and scientific community off guard. Now a handful of officials and academics are struggling to bring the country up to code. Geoff Brumfiel reports from the scene.

Geoff Brumfiel

doi:10.1038/440016a


Biochemistry: The iceman of svalbard p20

Some say that life began in fire. Hauke Trinks thinks it began in ice, and is bent on taking the hard route to prove it. Quirin Schiermeier tells the Arctic adventurer's tale.

Quirin Schiermeier

doi:10.1038/440020a


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Business

Toshiba goes nuclear p23

A Japanese giant is betting big on nuclear power — but not everyone thinks the gamble will pay off, as Kurt Kleiner reports.

Kurt Kleiner

doi:10.1038/440023a


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Correspondence

Top-down standards will not serve systems biology p24

John Quackenbush, Christian Stoeckert, Catherine Ball, Alvis Brazma, Robert Gentleman, Wolfgang Huber, Rafael Irizarry, Marc Salit, Gavin Sherlock, Paul Spellman and Neil Winegarden

doi:10.1038/440024a


Taxonomy on the fly in a European web project p24

Simon Tillier and Dave Roberts

doi:10.1038/440024b


Taxonomy: programmes developing in the South too p24

Carlos A. Joly

doi:10.1038/440024c


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Commentary

Global network could avert pandemics p25

Good surveillance is key to responding to a bird flu pandemic. Jean-Paul Chretien, David L. Blazes and their colleagues propose a new network of labs modelled on existing military facilities.

J. P. Chretien, J. C. Gaydos, J. L. Malone and D. L. Blazes

doi:10.1038/440025a


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Books and Arts

A Silent Spring for climate change? p27

Helping the public understand climate change is an important part of tackling the problem.

doi:10.1038/440027a


Film: Big trip to the red planet p28

doi:10.1038/440028a


Hidden depths p29

doi:10.1038/440029a


The chamber of wonders p29

doi:10.1038/440029b


Theatre: A defining moment for bioethics p30

doi:10.1038/440030a


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News and Views

地球科学:巨大地震を調べる

Earth science: Megathrust investigations p31

We know the basic events of 26 December 2004: a giant earthquake beneath the Indian Ocean generated a devastating tsunami. But geoscientists are still learning about processes initiated during the earthquake.

Charles J. Ammon

doi:10.1038/440031a


細胞生物学:年老いた核は形が崩れる

Cell biology: Ageing nucleus gets out of shape p32

In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal. An animal model shows similar malformations during normal ageing, corroborating the idea that genome instability underlies ageing.

Hannes Lans and Jan H. J. Hoeijmakers

doi:10.1038/440032a


ナノテクノロジー:きれい好きもほどほどに

Nanotechnology: How clean is too clean? p34

Silicon nanowires could form the building-blocks of future electronic devices, but under ultra-clean conditions, regulating their growth is difficult. Is the strictly controlled environment the problem?

Ulrich Gösele

doi:10.1038/440034a


生態学:中立説の予測を否定したサンゴ

Ecology: Corals fail a test of neutrality p35

Ecologists continue to wrestle with a central question in biodiversity studies — the prediction of species' distributions in various environments. A merger of different theories is the long-term prospect.

John M. Pandolfi

doi:10.1038/440035a


デバイス物理学:注目される電気ソリトン

Device physics: Electrical solitons come of age p36

Individual packets of light energy, known as optical solitons, have long been the darlings of communications engineers. Finally, their electrical siblings are getting a look in — and could become the new favourites.

Thomas H. Lee

doi:10.1038/440036a


50 & 100 years ago p37

doi:10.1038/440037a


行動生態学:コオロギ軍団をせきたてる

Behavioural ecology: Push on the marching crickets p38

Tim Lincoln

doi:10.1038/440038a


細胞生物学:鎖の切れ目

Cell biology: A break in the chain? p38

How chains of proteins link transmembrane cell–cell adhesion molecules to the cell's inner scaffold was standard textbook material. But recent research challenges the accepted model, opening a new chapter in the field.

Keith Burridge

doi:10.1038/440038b


構造生物学:特別製の同位体ラベル

Structural biology: Designer labels p40

An innovative approach to the isotopic labelling of proteins places the determination of the structures of larger proteins — particularly those in solution — within reach, while improving the accuracy of the method.

Stanley J. Opella

doi:10.1038/440040a


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Hypothesis

進化:イントロンと核・細胞質区画化の起源

Introns and the origin of nucleus–cytosol compartmentalization p41

William Martin and Eugene V. Koonin

doi:10.1038/nature04531


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Articles

地球:スマトラ-アンダマン巨大地震と関連したプレート境界変形

Plate-boundary deformation associated with the great Sumatra–Andaman earthquake p46

Cecep Subarya, Mohamed Chlieh, Linette Prawirodirdjo, Jean-Philippe Avouac, Yehuda Bock, Kerry Sieh, Aron J. Meltzner, Danny H. Natawidjaja and Robert McCaffrey

doi:10.1038/nature04522


生化学:NMRによるタンパク質構造決定へ向けた同位体標識法の最適化

Optimal isotope labelling for NMR protein structure determinations p52

Masatsune Kainosho, Takuya Torizawa, Yuki Iwashita, Tsutomu Terauchi, Akira Mei Ono and Peter Güntert

doi:10.1038/nature04525


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Letters

宇宙:磁場によってしぼり込まれた進化した星からのジェット

A magnetically collimated jet from an evolved star p58

Wouter H. T. Vlemmings, Philip J. Diamond and Hiroshi Imai

doi:10.1038/nature04466


宇宙:タイタンの大気中メタンの起源と考えられる間欠的なガス放出

Episodic outgassing as the origin of atmospheric methane on Titan p61

Gabriel Tobie, Jonathan I. Lunine and Christophe Sotin

doi:10.1038/nature04497


物理:重いフェルミオン超伝導体CeRhIn5の隠れた磁性と量子臨界性

Hidden magnetism and quantum criticality in the heavy fermion superconductor CeRhIn5 p65

Tuson Park, F. Ronning, H. Q. Yuan, M. B. Salamon, R. Movshovich, J. L. Sarrao and J. D. Thompson

doi:10.1038/nature04571


物理:シリコンナノワイヤーの成長に金の表面マイグレーションが及ぼす影響

The influence of the surface migration of gold on the growth of silicon nanowires p69

J. B. Hannon, S. Kodambaka, F. M. Ross and R. M. Tromp

doi:10.1038/nature04574


地球:イエローストーンカルデラでの隆起、熱的活動およびマグマの貫入

Uplift, thermal unrest and magma intrusion at Yellowstone caldera p72

Charles W. Wicks, Wayne Thatcher, Daniel Dzurisin and Jerry Svarc

doi:10.1038/nature04507


考古:ペルー南部における古代のトウモロコシ栽培と地域間交流

Early maize agriculture and interzonal interaction in southern Peru p76

Linda Perry, Daniel H. Sandweiss, Dolores R. Piperno, Kurt Rademaker, Michael A. Malpass, Adán Umire and Pablo de la Vera

doi:10.1038/nature04294


生態:サンゴ礁の多様性から生物多様性の中立説を論破する

Coral reef diversity refutes the neutral theory of biodiversity p80

Maria Dornelas, Sean R. Connolly and Terence P. Hughes

doi:10.1038/nature04534


疫学:英国の口蹄疫発生に対する個別対応式ワクチン接種の最適戦略

Optimal reactive vaccination strategies for a foot-and-mouth outbreak in the UK p83

Michael J. Tildesley, Nicholas J. Savill, Darren J. Shaw, Rob Deardon, Stephen P. Brooks, Mark E. J. Woolhouse, Bryan T. Grenfell and Matt J. Keeling

doi:10.1038/nature04324


進化:人工の遺伝子ネットワークにおいて有性生殖はロバストネスと負のエピスタシスを強化するような選択を行う

Sexual reproduction selects for robustness and negative epistasis in artificial gene networks p87

Ricardo B. R. Azevedo, Rolf Lohaus, Suraj Srinivasan, Kristen K. Dang and Christina L. Burch

doi:10.1038/nature04488


視覚:対象への視覚短期記憶を支える分離可能な神経機構

Dissociable neural mechanisms supporting visual short-term memory for objects p91

Yaoda Xu and Marvin M. Chun

doi:10.1038/nature04262


生理:赤血球での鉄同化にはマイトフェリンが不可欠である

Mitoferrin is essential for erythroid iron assimilation p96

George C. Shaw, John J. Cope, Liangtao Li, Kenneth Corson, Candace Hersey, Gabriele E. Ackermann, Babette Gwynn, Amy J. Lambert, Rebecca A. Wingert, David Traver, Nikolaus S. Trede, Bruce A. Barut, Yi Zhou, Emmanuel Minet, Adriana Donovan, Alison Brownlie, Rena Balzan, Mitchell J. Weiss, Luanne L. Peters, Jerry Kaplan, Leonard I. Zon and Barry H. Paw

doi:10.1038/nature04512


細胞:グアニル酸結合タンパク質が構造により誘発されるGTPからGMPへの連続的分解を行う仕組み

How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP p101

Agnidipta Ghosh, Gerrit J. K. Praefcke, Louis Renault, Alfred Wittinghofer and Christian Herrmann

doi:10.1038/nature04510


医学:AIDにより誘導されるc-myc-Igh転座における遺伝子不安定性とp53の役割

Role of genomic instability and p53 in AID-induced c-mycIgh translocations p105

Almudena R. Ramiro, Mila Jankovic, Elsa Callen, Simone Difilippantonio, Hua-Tang Chen, Kevin M. McBride, Thomas R. Eisenreich, Junjie Chen, Ross A. Dickins, Scott W. Lowe, Andre Nussenzweig and Michel C. Nussenzweig

doi:10.1038/nature04495


生理:走磁性細菌では酸性タンパク質がマグネトソームをフィラメント構造に沿って並べている

An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria p110

André Scheffel, Manuela Gruska, Damien Faivre, Alexandros Linaroudis, Jürgen M. Plitzko and Dirk Schüler

doi:10.1038/nature04382


生化学:センサリーロドプシン中でのシグナルの発生とそのトランスデューサーへの伝達

Development of the signal in sensory rhodopsin and its transfer to the cognate transducer p115

Rouslan Moukhametzianov, Johann P. Klare, Rouslan Efremov, Christian Baeken, Annika Göppner, Jörg Labahn, Martin Engelhard, Georg Büldt and Valentin I. Gordeliy

doi:10.1038/nature04520


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Naturejobs

Prospect

China syndrome p121

China is catching up with the West in science funding, education and investment.

Paul Smaglik

doi:10.1038/nj7080-121a


Special Report

After-school programmes p122

PhD students, postdocs and even senior scientists are taking continuing-education courses to improve their scientific 'hard skills' or branch out beyond the lab. Robert Rentzsch had a look around to see what's on offer.

Robert Rentzsch

doi:10.1038/nj7080-122a


Highlights

Highlight: The National Institutes of Health

doi:10.1038/nj0114


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Futures

Applied mathematical theology p126

You have a message.

Gregory Benford

doi:10.1038/440126a


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