Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 440, 32-34 (2 March 2006) | doi:10.1038/440032a; Published online 1 March 2006
Open Innovation Challenges
-
Single-cell Analysis Platform
This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
nature jobs
Environmental / Biotreatability Engineer
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Executive Director & Deans
- Translational Health Science and Technology Institute (THSTI); C / o National Institute of Immunology
- Delhi 110067 India
Cell biology: Ageing nucleus gets out of shape
Hannes Lans1 & Jan H. J. Hoeijmakers1
Abstract
In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal. An animal model shows similar malformations during normal ageing, corroborating the idea that genome instability underlies ageing.
Hutchinson–Gilford progeria syndrome (HGPS) produces signs of dramatically accelerated ageing, such as early cessation of growth, baldness at the age of two, progressive degeneration of the skin, muscle and bone, and often fatal atherosclerosis (arterial plaque build-up) in childhood. Like many other premature-ageing syndromes, HGPS does not recapitulate all aspects of ageing — for example, patients show no neurodegeneration or cancer predisposition.
- Hannes Lans and Jan H. J. Hoeijmakers are at the MGC-CBG Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000DR, Rotterdam, The Netherlands.
Email: J.Hoeijmakers@erasmusmc.nl
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Lamin mutations come of ageNature Medicine News and Views (01 Jun 2003)
Genome instability in progeria: when repair gets oldNature Medicine News and Views (01 Jul 2005)
RESEARCH
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activationNature Letters to Editor (22 Sep 2005)
Lamin B1 duplications cause autosomal dominant leukodystrophyNature Genetics Article (01 Oct 2006)
See all 4 matches for Research
