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Nature 440, 32-34 (2 March 2006) | doi:10.1038/440032a; Published online 1 March 2006

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Cell biology: Ageing nucleus gets out of shape

Hannes Lans1 & Jan H. J. Hoeijmakers1

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In certain premature-ageing syndromes, the architecture of the cell nucleus is abnormal. An animal model shows similar malformations during normal ageing, corroborating the idea that genome instability underlies ageing.

Hutchinson–Gilford progeria syndrome (HGPS) produces signs of dramatically accelerated ageing, such as early cessation of growth, baldness at the age of two, progressive degeneration of the skin, muscle and bone, and often fatal atherosclerosis (arterial plaque build-up) in childhood. Like many other premature-ageing syndromes, HGPS does not recapitulate all aspects of ageing — for example, patients show no neurodegeneration or cancer predisposition.

  1. Hannes Lans and Jan H. J. Hoeijmakers are at the MGC-CBG Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000DR, Rotterdam, The Netherlands.
    Email: J.Hoeijmakers@erasmusmc.nl

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