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Nature 439, 798-799 (16 February 2006) | doi:10.1038/439798a; Published online 15 February 2006

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Genetics: Copies count

Joseph H. Nadeau1 & Charles Lee2

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Some genes have more than one copy, and the copy number can differ among individuals. But does this variation affect the person involved? It seems susceptibility to certain common diseases can be altered.

Each of our kidneys consists of about one million glomeruli — clusters of tiny blood vessels that together filter a remarkable 50 gallons of blood each day. Filtering separates waste products for excretion while retaining water and other vital substances such as glucose and proteins.

  1. Joseph H. Nadeau is in the Department of Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
    Email: jhn4@case.edu
  2. Charles Lee is in the Division of Cytogenetics, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 20 Shattuck Street, Boston, Massachusetts 02115, USA.
    Email: clee@rics.bwh.harvard.edu

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