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Nature 439, 794-795 (16 February 2006) | doi:10.1038/439794a; Published online 15 February 2006
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Developmental biology: Two paths to silence merge
Panthea Taghavi1 & Maarten van Lohuizen1
Abstract
To maintain their identity across generations, specialized cells must heritably repress swathes of genes — keeping active only genes necessary for the cell's purpose. Now it seems two repressive pathways join forces.
Even though cells of all developmental stages carry the same DNA, they have their own identity, defined by the combination of proteins expressed in each cell. These expression patterns, although set early during development, are reproduced in each mature, specialized cell later in life, over many cell divisions.
- Panthea Taghavi and Maarten van Lohuizen are in the Division of Molecular Genetics, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands.
Email: m.v.lohuizen@nki.nl
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