Supplementary information
From the following article:
Restoring function in exhausted CD8 T cells during chronic viral infection
Daniel L. Barber, E. John Wherry, David Masopust, Baogong Zhu, James P. Allison, Arlene H. Sharpe, Gordon J. Freeman and Rafi Ahmed
Nature 439, 682-687 (9 February 2006)
doi:10.1038/nature04444
Supplementary Figure 1
Breadth of the CD8 T cell response after PD-L1 blockade in chronically infected mice.
Supplementary Figure 2
Anti-PD-1 mAb enhances virus specific CD8 T cell responses.
Supplementary Figure 3
Blockade of the CTLA-4 inhibitory pathway has no effect on T cell responses or viral control during chronic LCMV infection.
Supplementary Figure 4
Sustained increases in virus-specific CD8 T cells after transient PD-L1 blockade during chronic infection.
Supplementary Methods
Additional descriptions of the methods used in this study.
DOWNLOAD BROWSER PLUGINS AND OTHER APPLICATIONS
Movie files
PDF douments
Text documents
PostScript documents
Flash movies
Audio files
- Apple iTunes (PC or Mac)
- QuickTime Player (PC or Mac)
- Realplayer (PC or Mac)
- Windows Media player (PC only)
