Figures and Tables
From the following article:
Restoring function in exhausted CD8 T cells during chronic viral infection
Daniel L. Barber, E. John Wherry, David Masopust, Baogong Zhu, James P. Allison, Arlene H. Sharpe, Gordon J. Freeman and Rafi Ahmed
Nature 439, 682-687 (9 February 2006)
doi:10.1038/nature04444
Figure 1
PD-1 is highly upregulated by exhausted CD8 T cells during chronic infection.
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Figure 2
Blockade of the PD-1/PD-L1 inhibitory pathway increases CD8 T-cell function and enhances the clearance of chronic viral infection.
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Figure 3
Restoration of function in 'helpless' exhausted CD8 T cells.
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Figure 4
Proliferation of exhausted CD8 T cells in both lymphoid and non-lymphoid tissues after anti-PD-L1 treatment.
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Figure 5
PD-L1-/- mice make normal CD8 T-cell responses after LCMV Armstrong infection but succumb to clone 13 infection owing to immunopathology.
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