FIGURE 5. PD-L1-/- mice make normal CD8 T-cell responses after LCMV Armstrong infection but succumb to clone 13 infection owing to immunopathology.
From the following article:
Restoring function in exhausted CD8 T cells during chronic viral infection
Daniel L. Barber, E. John Wherry, David Masopust, Baogong Zhu, James P. Allison, Arlene H. Sharpe, Gordon J. Freeman and Rafi Ahmed
Nature 439, 682-687 (9 February 2006)
doi:10.1038/nature04444
a, PD-L1-/- and littermate control mice were infected with LCMV Armstrong, and virus-specific CD8 T cells were analysed in the peripheral blood mononuclear cells (PBMC) using the tetramers GP33 (diamonds) and GP276 (circles). b, PD-L1-/- or littermate control mice were infected with clone 13 and survival was monitored.