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Nature 439, 612-616 (2 February 2006) | doi:10.1038/nature04487;
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Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Tier II Canada Research Chair in Cellular Science and Human Health
- Concordia University
- Montreal, Quebec Canada
Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus
The critical viral components for packaging DNA, recognizing and binding to host cells, and injecting the condensed DNA into the host are organized at a single vertex of many icosahedral viruses. These component structures do not share icosahedral symmetry and cannot be resolved using a conventional icosahedral averaging method.
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