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Nature 439, 599-603 (28 December 2005) | doi:10.1038/nature04247;
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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
During mammalian ontogeny, haematopoietic stem cells (HSCs) translocate from the fetal liver to the bone marrow, where haematopoiesis occurs throughout adulthood. Unique features of bone that contribute to a microenvironmental niche for stem cells might include the known high concentration of calcium ions at the HSC-enriched endosteal surface.
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