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Nature 439, 542-543 (2 February 2006) | doi:10.1038/439542a; Published online 1 February 2006

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Molecular biology: Prime-time progress

Stephen D. Bell1

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DNA is duplicated within a complex macromolecular machine. Insights into how replication begins and how this is coordinated with progression of DNA synthesis come from a diverse range of sources.

DNA is replicated by unzipping the double helix to expose the bases that act as a template for copying the genetic material. Both strands of DNA serve as templates, and thus one double helix becomes two.

  1. Stephen D. Bell is in the MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK.
    Email: sb419@hutchison-mrc.cam.ac.uk

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