Table of contents
Volume 439 Number 7074 pp243-368
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Editorials
Standards for papers on cloning p243
In the wake of the Hwang scandal, journals have been reviewing their refereeing procedures. Following a survey of experts, here are Nature's thoughts on papers about cloning, with an invitation to comment.
doi:10.1038/439243a
A new ERA? p244
A novel component of the European Research Area will require national funders' cooperation.
doi:10.1038/439244a
Circulation challenge p244
The lack of monitoring of ocean currents must be addressed quickly.
doi:10.1038/439244b
News
Alarms ring over bird flu mutations p248
Turkish virus shows increased affinity for humans.
Declan Butler
doi:10.1038/439248a
Doctor admits Lancet study is fiction p248
Faked data keeps spotlight on peer review.
Emma Marris
doi:10.1038/439248b
Will Germany choose a fair élite? p249
Contest to select top universities accused of political bias.
doi:10.1038/439249a
Astronomers told to cut it out p250
US observatories face battle for survival.
Geoff Brumfiel
doi:10.1038/439250a
Snapshot: Cloudshine is a stellar snap for Harvard duo p250
Gas clouds in starlight captured on camera.
doi:10.1038/439250b
Sidelines p252
doi:10.1038/439252a
Journals submit to scrutiny of their peer-review process p252
Largest-ever study gains unprecedented access.
Jim Giles
doi:10.1038/439252b
Promises to clean up industry fail to convince p253
Environmentalists unimpressed by companies' voluntary standards.
Carina Dennis
doi:10.1038/439253a
Stress makes medics ever gloomier p254
US medical schools have high incidence of clinical depression.
Helen Pearson
doi:10.1038/439254a
News in brief p255
doi:10.1038/439255a
Correction p255
doi:10.1038/439255b
News Features
Climate change: A sea change p256
A collapse in ocean currents triggered by global warming could be catastrophic, but only now is the Atlantic circulation being properly monitored. Quirin Schiermeier investigates.
doi:10.1038/439256a
Palaeontology: Hooked on fossils p262
For decades, much of the early history of fish evolution was locked away in rocks in China. Rex Dalton tracks down the scientist who brought many of the remains to the surface.
doi:10.1038/439262a
Business
Hwang scandal hits Korean biotech hard p265
Ichiko Fuyuno
doi:10.1038/439265a
In brief p265
doi:10.1038/439265b
Correspondence
Risks of resurrecting 1918 flu virus outweigh benefits p266
Dr Jan van Aken
doi:10.1038/439266a
Value of high-protein diet is clearer than drawbacks p266
Peter Clifton
doi:10.1038/439266b
Saintly helpers at hand in Renaissance hospital art p266
Piero Dolara
doi:10.1038/439266c
Humour of gene names lost in translation to patients p266
Ken Maclean
doi:10.1038/439266d
Commentary
Experiments in social responsibility p267
Pursuing drugs for neglected diseases is not a traditional part of the pharmaceutical company portfolio. But Paul Herrling of Novartis finds that it brings welcome changes both within and outside the industry.
doi:10.1038/439267a
See also: Editor's summary
Books and Arts
Experimental fiction p269
Publishers could do a lot more to promote 'lab lit', a genre of novel set in the world of science.
Jennifer Rohn
doi:10.1038/439269a
Exhibition: Geological fireworks p270
doi:10.1038/439270a
Living with infection p270
Tony McMichael reviews Diseases and Human Evolution by Ethne Barnes
doi:10.1038/439270b
Unearthing religion p271
Nicholas J. Conard reviews Inside the Neolithic Mind: Consciousness, Cosmos and the Realm of the Gods by David Lewis-Williams & David Pearce
doi:10.1038/439271a
News and Views
Condensed-matter physics: Great moments in disorder p273
An array of nanomagnets has been designed to resemble the disordered magnetic state known as 'spin ice'. This could transform our understanding of disordered matter and, potentially, lead to new technologies.
Steven T. Bramwell
doi:10.1038/439273a
See also: Editor's summary
Cancer biology: Signatures guide drug choice p274
Cancer drugs are increasingly designed to target specific cell-signalling pathways. When, and in what combination, these drugs should be used might be judged by analysing the gene expression signature of the tumour.
Julian Downward
doi:10.1038/439274a
See also: Editor's summary
Atmospheric chemistry: Biogenic bromine p275
Among other effects, bromine released by biological processes in the oceans apparently reduces ozone levels in the troposphere. This source may be a link between atmospheric composition and climate change.
Ross J. Salawitch
doi:10.1038/439275a
Plant biology: Abscisic acid in bloom p277
To survive environmental stresses, plants must respond to the hormone abscisic acid. The receptors for this hormone have remained elusive, but one receptor with unique functions in flowering has now been identified.
Julian I. Schroeder & Josef M Kuhn
doi:10.1038/439277a
See also: Editor's summary
50 & 100 years ago p277
doi:10.1038/439277b
Chemical ecology: In defence of maize p278
Tim Lincoln
doi:10.1038/439278a
Nuclear physics: Odd couple decays p279
The decay of proton-rich nuclei by the emission of a single proton has been known about for some time, and is well understood. The latest observation of two-proton emission, however, will provoke some head-scratching.
Juha Äystö
doi:10.1038/439279a
See also: Editor's summary
Obituary: Theodore H. Bullock (1915–2005) p280
Trailblazer in neurobiology.
Günther K. H. Zupanc
doi:10.1038/439280a
Brief Communications
Superplastic carbon nanotubes p281
Conditions have been discovered that allow extensive deformation of rigid single-walled nanotubes.
J. Y. Huang, S. Chen, Z. Q. Wang, K. Kempa, Y. M. Wang, S. H. Jo, G. Chen, M. S. Dresselhaus & Z. F. Ren
doi:10.1038/439281a
First paragraph | Full Text | PDF (392K) | Supplementary information
Articles
A brain-specific microRNA regulates dendritic spine development p283
Gerhard M. Schratt, Fabian Tuebing, Elizabeth A. Nigh, Christina G. Kane, Mary E. Sabatini, Michael Kiebler & Michael E. Greenberg
doi:10.1038/nature04367
Abstract | Full Text | PDF (1,187K) | Supplementary information
See also: Editor's summary
The RNA-binding protein FCA is an abscisic acid receptor p290
Fawzi A. Razem, Ashraf El-Kereamy, Suzanne R. Abrams & Robert D. Hill
doi:10.1038/nature04373
Abstract | Full Text | PDF (415K) | Supplementary information
See also: Editor's summary | News and Views by Schroeder & Kuhn
Letters
A late Miocene dust shower from the break-up of an asteroid in the main belt p295
Kenneth A. Farley, David Vokrouhlický, William F. Bottke & David Nesvorný
doi:10.1038/nature04391
First paragraph | Full Text | PDF (192K) | Supplementary information
See also: Editor's summary
Proton–proton correlations observed in two-proton radioactivity of 94Ag p298
Ivan Mukha, Ernst Roeckl, Leonid Batist, Andrey Blazhev, Joachim Döring, Hubert Grawe, Leonid Grigorenko, Mark Huyse, Zenon Janas, Reinhard Kirchner, Marco La Commara, Chiara Mazzocchi, Sam L. Tabor & Piet Van Duppen
doi:10.1038/nature04453
First paragraph | Full Text | PDF (454K) | Supplementary information
See also: Editor's summary | News and Views by Äystö
Artificial 'spin ice' in a geometrically frustrated lattice of nanoscale ferromagnetic islands p303
R. F. Wang, C. Nisoli, R. S. Freitas, J. Li, W. McConville, B. J. Cooley, M. S. Lund, N. Samarth, C. Leighton, V. H. Crespi & P. Schiffer
doi:10.1038/nature04447
First paragraph | Full Text | PDF (361K)
See also: Editor's summary | News and Views by Bramwell
Dynamical fracture instabilities due to local hyperelasticity at crack tips p307
Markus J. Buehler & Huajian Gao
doi:10.1038/nature04408
First paragraph | Full Text | PDF (357K) | Supplementary information
Low sea level rise projections from mountain glaciers and icecaps under global warming p311
Sarah C. B. Raper & Roger J. Braithwaite
doi:10.1038/nature04448
First paragraph | Full Text | PDF (376K) | Supplementary information
See also: Editor's summary
Thallium isotopic evidence for ferromanganese sediments in the mantle source of Hawaiian basalts p314
Sune G. Nielsen, Mark Rehkämper, Marc D. Norman, Alex N. Halliday & Darrell Harrison
doi:10.1038/nature04450
First paragraph | Full Text | PDF (196K)
Tetrapod-like middle ear architecture in a Devonian fish p318
Martin D. Brazeau & Per E. Ahlberg
doi:10.1038/nature04196
First paragraph | Full Text | PDF (390K) | Supplementary information
See also: Editor's summary
Reduced mixing generates oscillations and chaos in the oceanic deep chlorophyll maximum p322
Jef Huisman, Nga N. Pham Thi, David M. Karl & Ben Sommeijer
doi:10.1038/nature04245
First paragraph | Full Text | PDF (2,477K) | Supplementary information
See also: Editor's summary
Dissection of epistasis in oligogenic Bardet–Biedl syndrome p326
Jose L. Badano, Carmen C. Leitch, Stephen J. Ansley, Helen May-Simera, Shaneka Lawson, Richard Alan Lewis, Philip L. Beales, Harry C. Dietz, Shannon Fisher & Nicholas Katsanis
doi:10.1038/nature04370
First paragraph | Full Text | PDF (505K) | Supplementary information
See also: Editor's summary
DNA sequence and analysis of human chromosome 8 p331
Chad Nusbaum, Tarjei S. Mikkelsen, Michael C. Zody, Shuichi Asakawa, Stefan Taudien, Manuel Garber, Chinnappa D. Kodira, Mary G. Schueler, Atsushi Shimizu, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Nicole R. Allen, Scott Anderson, Teruyo Asakawa, Karin Blechschmidt, Toby Bloom, Mark L. Borowsky, Jonathan Butler, April Cook, Benjamin Corum, Kurt DeArellano, David DeCaprio, Kathleen T. Dooley, Lester Dorris, III, Reinhard Engels, Gernot Glöckner, Nabil Hafez, Daniel S. Hagopian, Jennifer L. Hall, Sabine K. Ishikawa, David B. Jaffe, Asha Kamat, Jun Kudoh, Rüdiger Lehmann, Tashi Lokitsang, Pendexter Macdonald, John E. Major, Charles D. Matthews, Evan Mauceli, Uwe Menzel, Atanas H. Mihalev, Shinsei Minoshima, Yuji Murayama, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Sinéad B. O'Leary, Keith O'Neill, Stephen C. J. Parker, Andreas Polley, Christina K. Raymond, Kathrin Reichwald, Joseph Rodriguez, Takashi Sasaki, Markus Schilhabel, Roman Siddiqui, Cherylyn L Smith, Tam P. Sneddon, Jessica A. Talamas, Pema Tenzin, Kerri Topham, Vijay Venkataraman, Gaiping Wen, Satoru Yamazaki, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Andre Rosenthal, Bruce W. Birren, Matthias Platzer, Nobuyoshi Shimizu & Eric S. Lander
doi:10.1038/nature04406
First paragraph | Full Text | PDF (302K) | Supplementary information
See also: Editor's summary
Top-down gain control of the auditory space map by gaze control circuitry in the barn owl p336
Daniel E. Winkowski & Eric I. Knudsen
doi:10.1038/nature04411
First paragraph | Full Text | PDF (378K)
See also: Editor's summary
Constant darkness is a circadian metabolic signal in mammals p340
Jianfa Zhang, Krista Kaasik, Michael R. Blackburn & Cheng Chi Lee
doi:10.1038/nature04368
First paragraph | Full Text | PDF (355K) | Supplementary information
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population p344
Marco Vignuzzi, Jeffrey K. Stone, Jamie J. Arnold, Craig E. Cameron & Raul Andino
doi:10.1038/nature04388
First paragraph | Full Text | PDF (336K) | Supplementary information
See also: Editor's summary
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting 
-cells p349
Oleg Dyachok, Yegor Isakov, Jenny Sågetorp & Anders Tengholm
doi:10.1038/nature04410
First paragraph | Full Text | PDF (346K) | Supplementary information
Oncogenic pathway signatures in human cancers as a guide to targeted therapies p353
Andrea H. Bild, Guang Yao, Jeffrey T. Chang, Quanli Wang, Anil Potti, Dawn Chasse, Mary-Beth Joshi, David Harpole, Johnathan M. Lancaster, Andrew Berchuck, John A. Olson, Jr, Jeffrey R. Marks, Holly K. Dressman, Mike West & Joseph R. Nevins
doi:10.1038/nature04296
First paragraph | Full Text | PDF (476K) | Supplementary information
See also: Editor's summary | News and Views by Downward
BRAF mutation predicts sensitivity to MEK inhibition p358
David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose M. Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith Sebolt-Leopold, William R. Sellers & Neal Rosen
doi:10.1038/nature04304
First paragraph | Full Text | PDF (530K) | Supplementary information
See also: Editor's summary | News and Views by Downward
Naturejobs
ProspectSpeaking in tongues p363
Host institutes should make foreign students feel more at home.
Paul Smaglik
doi:10.1038/nj7074-363a
Special Report
Dream big p364
Being an astronaut, video-game designer or museum curator may be every child scientist's dream. Kendall Powell talks to the creative scientists who followed the fantasy.
Kendall Powell
doi:10.1038/nj7074-364a
Career Views
Philip Bucksbaum, director, Stanford Ultrafast Science Center, Stanford, California p366
Virginia Gewin
doi:10.1038/nj7074-366a
Back to high school p366
Marilyn Brodie
doi:10.1038/nj7074-366b
The winding road p366
Tshaka Cunningham
doi:10.1038/nj7074-366c
Futures
For he on honeydew hath fed... p368
...and drunk the milk of Paradise.
Paul Smaglik
doi:10.1038/439368a
