FIGURE 2. 8p and 8q pericentromeric contigs extend into chromosome 8-specific higher-order alpha satellite, D8Z2.

From the following article:

DNA sequence and analysis of human chromosome 8

Chad Nusbaum, Tarjei S. Mikkelsen, Michael C. Zody, Shuichi Asakawa, Stefan Taudien, Manuel Garber, Chinnappa D. Kodira, Mary G. Schueler, Atsushi Shimizu, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Nicole R. Allen, Scott Anderson, Teruyo Asakawa, Karin Blechschmidt, Toby Bloom, Mark L. Borowsky, Jonathan Butler, April Cook, Benjamin Corum, Kurt DeArellano, David DeCaprio, Kathleen T. Dooley, Lester Dorris, III, Reinhard Engels, Gernot Glöckner, Nabil Hafez, Daniel S. Hagopian, Jennifer L. Hall, Sabine K. Ishikawa, David B. Jaffe, Asha Kamat, Jun Kudoh, Rüdiger Lehmann, Tashi Lokitsang, Pendexter Macdonald, John E. Major, Charles D. Matthews, Evan Mauceli, Uwe Menzel, Atanas H. Mihalev, Shinsei Minoshima, Yuji Murayama, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Sinéad B. O'Leary, Keith O'Neill, Stephen C. J. Parker, Andreas Polley, Christina K. Raymond, Kathrin Reichwald, Joseph Rodriguez, Takashi Sasaki, Markus Schilhabel, Roman Siddiqui, Cherylyn L Smith, Tam P. Sneddon, Jessica A. Talamas, Pema Tenzin, Kerri Topham, Vijay Venkataraman, Gaiping Wen, Satoru Yamazaki, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Andre Rosenthal, Bruce W. Birren, Matthias Platzer, Nobuyoshi Shimizu & Eric S. Lander

Nature 439, 331-335(19 January 2006)

doi:10.1038/nature04406

BACK TO ARTICLE

The pericentromeric region of chromosome 8 is shown as a truncated ideogram with the extent of sequence coverage shown below by black bars. Dotter plots show self–self alignments of the most proximal approx100 kb from each arm including approx36 kb of the chromosome-specific alpha satellite array (D8Z2). Junctions between the arm-specific satellite region and D8Z2 are marked with blue arrows. Dark blocks indicate the highly repetitive nature of the satellite region and mark similarity between monomers within each satellite family. Gaps in the dark blocks occur where interspersed elements (LINEs, SINEs and long terminal repeats) interrupt the satellite sequences. In the alpha satellite array dotter plot (bottom), D8Z2 from 8p (approx18 kb) is joined with that of 8q (approx18 kb). The plot reveals the periodic nature of the centromeric, higher-order alpha satellite array with black horizontal lines indicating near identity of sequences spaced at approx1.9-kb intervals. The regions outlined in blue are self–self alignments ('8p' and '8q'), whereas the remaining rectangular region of the plot is an alignment of 8p versus 8q D8Z2.

BACK TO ARTICLE