FIGURE 3. 5'-AMP-induced mClps expression and torpor in LD mice.

From the following article:

Constant darkness is a circadian metabolic signal in mammals

Jianfa Zhang, Krista Kaasik, Michael R. Blackburn & Cheng Chi Lee

Nature 439, 340-343(19 January 2006)

doi:10.1038/nature04368

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a, Northern blot analysis of mClps expression in liver of wild-type mice injected with saline or 5'-AMP. Gapdh levels were monitored as an internal control. b, CBT of wild-type mice injected with saline or 5'-AMP. Filled squares, saline; open circles, 0.15 micromol AMP g-1; filled circles, 1.5 micromol AMP g-1; crosses, 5.0 micromol AMP g-1; open squares, 10.0 micromol AMP g-1. Error bars indicate s.e.m. (n = 3). c, CBT of wild-type and mPer1-/-/mPer2m/m mice injected with saline or 5'-AMP. mPer1-/-/mPer2m/m mice: open squares, 1.5 micromol AMP g-1; filled circles, saline. Wild-type mice: crosses, 1.5 micromol AMP g-1; open circles, saline. Error bars indicate s.e.m. (n = 3). We observed no apparent adverse effects on the torpid mice after their CBT had returned to 37 °C.

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