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From the following article:

BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose M. Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith Sebolt-Leopold, William R. Sellers & Neal Rosen

Nature 439, 358-362(19 January 2006)

doi:10.1038/nature04304

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

The BRAF(V600E) mutation confers sensitivity to the MEK inhibitor CI-1040.

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Figure 2

Chemical sensitivity associated with mutant BRAF and RAS class distinctions.

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Figure 3

MEK inhibition causes loss of D-cyclin expression, RB hypophosphorylation and G1 arrest in BRAF mutant cancer cells.

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Figure 4

PD0325901 completely suppresses the growth of BRAF(V600E) mutant xenografts.

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