FIGURE 4. PD0325901 completely suppresses the growth of BRAF(V600E) mutant xenografts.
From the following article:
BRAF mutation predicts sensitivity to MEK inhibition
David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose M. Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith Sebolt-Leopold, William R. Sellers & Neal Rosen
Nature 439, 358-362(19 January 2006)
doi:10.1038/nature04304
a, PD0325901 suppressed the growth of SKMEL28 (BRAF(V600E)) xenografts at both the 5 and 25 mg kg-1 dose levels. b, c, In contrast, 5 mg kg-1 PD0325901 only delayed the growth of SKMEL103 (RAS(Q61R)) and SKMEL31 (RAS/RAF-WT) xenografts, with complete growth suppression requiring the higher dose. d, BT-474 xenografts (RAS/RAF-WT) were refractory to MEK inhibition (n = 10 mice per group). e, f, PD0325901 reduced p-ERK levels in both SKMEL28 and BT-474 xenograft tumours but caused downregulation of D-cyclins, induction of p27 and hypophosphorylation of RB, and a decline in the proliferative index only in the SKMEL28 xenografts. Tumour lysates were derived from mice euthanized 8 h after the final treatment. All error bars indicate standard error.
