FIGURE 2. Chemical sensitivity associated with mutant BRAF and RAS class distinctions.
From the following article:
BRAF mutation predicts sensitivity to MEK inhibition
David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose M. Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith Sebolt-Leopold, William R. Sellers & Neal Rosen
Nature 439, 358-362(19 January 2006)
doi:10.1038/nature04304
a–c, Colourgrams show BRAF mutant (a) or RAS mutant (b) versus the remaining NCI60 cells, or for mutant RAS versus mutant BRAF lines (c). Columns denote NCI60 cell lines; rows denote compounds; colour denotes the number of standard deviations above (red) or below (blue) the mean for all cell lines (top 100 compounds for each class distinction shown; see Methods). NSC numbers, names, variance-fixed T-scores (absolute values; see Methods) and asymptotic P values are shown for top-scoring compounds. Blue font indicates known MEK inhibitors. d, Relative GI50 values for the MEK inhibitor hypothemycin in non-haematological NCI60 cell lines. Black bars indicate BRAF wild-type cells; blue bars indicate BRAF(V600E) cells; asterisks indicate non-melanoma cell lines with the BRAF(V600E) mutation.
