FIGURE 3. Patterns of pathway deregulation in human cancers.

a, Hierarchical clustering of predictions of pathway deregulation in samples of human lung tumours (left panel). Prediction of Ras, Myc, E2F3, -catenin and Src pathway status for each tumour sample was independently determined using supervised binary regression analysis, as described. Red indicates high probability of pathway activation, with blue indicating a low probability. Patterns in the tumour pathway predictions were identified by hierarchical clustering, and separate clusters are indicated by coloured dendograms. Kaplan–Meier survival analysis for lung cancer patients based on pathway clusters (right panel). Patient clusters with correlative pathway deregulation shown in the left panel correspond to clusters comprising each independent survival curve. Black tick marks represent censored patients. b, Breast cancer. Same as for a. c, Ovarian cancer. Same as for a.