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Nature 439, 134-135 (12 January 2006) | doi:10.1038/439134a; Published online 11 January 2006

Prion disease: The shape of things to come

Roxanne Khamsi1

  1. Roxanne Khamsi reports for Nature from New York.
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A number of fatal brain diseases are linked to misfolded proteins, an effect researchers are mimicking in the lab. But as they generate new versions of these malformed molecules, could they be creating a monster? Roxanne Khamsi finds out.

In a secure lab in Texas, five machines are purring away quietly. Working through the night, these boxes churn out billions of malformed proteins.

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