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Nature 439, 89-94 (23 November 2005) | doi:10.1038/nature04263;
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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
Herpes simplex virus 2 (HSV-2) infection causes significant morbidity and is an important cofactor for the transmission of HIV infection. A microbicide to prevent sexual transmission of HSV-2 would contribute substantially to controlling the spread of HIV and other infections.
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