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Editorials

No new start at Los Alamos p1

A fresh contract for the management of the New Mexico nuclear-weapons laboratory offers it little prospect of a happy and prosperous new year.

doi:10.1038/439001a


Developing resistance p1

A study of opposition to a vaccine for children shows how the public can lose faith in science.

doi:10.1038/439001b


Sound science p2

Audio files downloaded from the Internet can enrich scientific communication.

doi:10.1038/439002a


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Research Highlights

Research highlights p4

doi:10.1038/439004a


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News

Mashups mix data into global service p6

Is this the future for scientific analysis?

Declan Butler

doi:10.1038/439006a


Intelligent design verdict set to sway other cases p6

Failure in court sets offers evolutionary precedent.

Emma Marris

doi:10.1038/439006b


Croatian scientists call for openness over funding p7

Researchers demand transparency for grant awards.

Alison Abbott

doi:10.1038/439007a


Blow follows blow for stem-cell work p8

South Korean cloning scandal deepens.

David Cyranoski

doi:10.1038/439008a


Los Alamos bosses ditched after decade of scandals p8

US weapons lab makes a fresh start.

Emma Marris

doi:10.1038/439008b


News in brief p9

doi:10.1038/438902a


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News Features

Our Universe: Outrageous fortune p10

A growing number of cosmologists and string theorists suspect the form of our Universe is little more than a coincidence. Are these harmless thought experiments, or a challenge to science itself? Geoff Brumfiel investigates.

doi:10.1038/439010a


Ethiopia: Awash with fossils p14

The Afar region of Ethiopia is littered with traces of the earliest humans. Rex Dalton gets on the trail with a team of devoted experts who just live for the next find.

doi:10.1038/439014a

See also: Editor's summary


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Business

More than just hot air? p17

With the launch of an alternative-energy division, BP is taking steps to show that it is serious about 'clean' technology. Emma Marris reports.

doi:10.1038/439017a

See also: Editor's summary


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Correspondence

Power games cause sparks in physics, but biologists have learnt from evolution p18

Peter Hietz and Manuela Winkler

doi:10.1038/439018a


Power clashes limit science and reflect archaic values p18

María Uriarte, Kathleen Weathers and Valerie Eviner

doi:10.1038/439018b


Science is an adventure, not a battle p18

David Kleinfeld

doi:10.1038/439018c


Bias may be unintentional but it's still there p18

Cathy W. S. Chen and Ying-Hen Hsieh

doi:10.1038/439018d


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Books and Arts

A robust approach p19

The functional overlap between different components protects biological systems.

Eörs Szathmáry reviews Robustness and Evolvability in Living Systems by Andreas Wagner

doi:10.1038/439019a


Psychology in the real world? p20

Steve Blinkhorn reviews World As Laboratory: Experiments with Mice, Mazes, and Men by Rebecca Lemov

doi:10.1038/439020a


Exhibition: Casting a long shadow p21

Laura Spinney reviews Melancholy: Genius and Insanity in the West

doi:10.1038/439021a


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News and Views

Developmental neuroscience: Two gradients are better than one p23

Wiring up retinal neurons to the correct brain region during development is a feat of precision growth. A novel directional cue repels retinal neuron fibres, acting as a counterbalance to a known attractive signal.

Liqun Luo

doi:10.1038/439023a

See also: Editor's summary


Planetary science: The ferryman casts his shadow p24

The most accurate way of determining the size of some bodies in the Solar System is to observe them as they pass across the face of a star. In the case of Charon, Pluto's largest satellite, it's been a long wait.

David J. Tholen

doi:10.1038/439024a

See also: Editor's summary


Oceanography: A phosphate alternative p25

A major player among the phytoplankton can exploit a source of phosphorus previously thought to be unavailable to it. That ability may provide an ecological advantage in nutrient-depleted regions of the open ocean.

Sergio A. Sañudo-Wilhelmy

doi:10.1038/439025a

See also: Editor's summary


Volcanoes: Interpreting inclusive evidence p26

Crystallization of ascending magma may affect the style of volcanic activity. Pockets of melt incorporated into crystals provide windows on processes that occur several kilometres below Earth's surface.

Julia E. Hammer

doi:10.1038/439026a


Biological physics: Harmonies from noise p27

Do random environments make for random responses to them? Mathematical models suggest that this is not always the case — adding noise could create synchronous oscillations in cell–cell signalling systems.

Michael Springer and Johan Paulsson

doi:10.1038/439027a


50 & 100 years ago p28

doi:10.1038/439028a


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Brief Communications

Fisheries: Deep-sea fishes qualify as endangered p29

A shift from shelf fisheries to the deep sea is exhausting late-maturing species that recover only slowly.

Jennifer A. Devine, Krista D. Baker and Richard L. Haedrich

doi:10.1038/439029a

See also: Editor's summary


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Brief Communications Arising

Ecology: Mechanisms for consumer diversity pE1

Takehito Yoshida, Laura E. Jones, Stephen P. Ellner and Nelson G. Hairston, Jr

doi:10.1038/nature04526


Ecology: Mechanisms for consumer diversity (Reply) pE2

William A. Nelson, Edward McCauley and Frederick J. Wrona

doi:10.1038/nature04527


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Articles

Wnt–Ryk signalling mediates medial–lateral retinotectal topographic mapping p31

Adam M. Schmitt, Jun Shi, Alex M. Wolf, Chin-Chun Lu, Leslie A. King and Yimin Zou

doi:10.1038/nature04334

See also: Editor's summary | News and Views by Luo


Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation p38

Hsien-Sheng Yin, Xiaolin Wen, Reay G. Paterson, Robert A. Lamb and Theodore S. Jardetzky

doi:10.1038/nature04322

See also: Editor's summary


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Letters

Radioactive 26Al from massive stars in the Galaxy p45

Roland Diehl, Hubert Halloin, Karsten Kretschmer, Giselher G. Lichti, Volker Schönfelder, Andrew W. Strong, Andreas von Kienlin, Wei Wang, Pierre Jean, Jürgen Knödlseder, Jean-Pierre Roques, Georg Weidenspointner, Stephane Schanne, Dieter H. Hartmann, Christoph Winkler and Cornelia Wunderer

doi:10.1038/nature04364

See also: Editor's summary


Charon's radius and atmospheric constraints from observations of a stellar occultation p48

A. A. S. Gulbis, J. L. Elliot, M. J. Person, E. R. Adams, B. A. Babcock, M. Emilio, J. W. Gangestad, S. D. Kern, E. A. Kramer, D. J. Osip, J. M. Pasachoff, S. P. Souza and T. Tuvikene

doi:10.1038/nature04276

See also: Editor's summary | News and Views by Tholen


Charon's size and an upper limit on its atmosphere from a stellar occultation p52

B. Sicardy, A. Bellucci, E. Gendron, F. Lacombe, S. Lacour, J. Lecacheux, E. Lellouch, S. Renner, S. Pau, F. Roques, T. Widemann, F. Colas, F. Vachier, R. Vieira Martins, N. Ageorges, O. Hainaut, O. Marco, W. Beisker, E. Hummel, C. Feinstein, H. Levato, A. Maury, E. Frappa, B. Gaillard, M. Lavayssière, M. Di Sora, F. Mallia, G. Masi, R. Behrend, F. Carrier, O. Mousis, P. Rousselot, A. Alvarez-Candal, D. Lazzaro, C. Veiga, A. H. Andrei, M. Assafin, D. N. da Silva Neto, C. Jacques, E. Pimentel, D. Weaver, J.-F. Lecampion, F. Doncel, T. Momiyama and G. Tancredi

doi:10.1038/nature04351

See also: Editor's summary | News and Views by Tholen


Structural diversity in binary nanoparticle superlattices p55

Elena V. Shevchenko, Dmitri V. Talapin, Nicholas A. Kotov, Stephen O'Brien and Christopher B. Murray

doi:10.1038/nature04414

See also: Editor's summary


Abrupt reversal in ocean overturning during the Palaeocene/Eocene warm period p60

Flavia Nunes and Richard D. Norris

doi:10.1038/nature04386

See also: Editor's summary


Three-dimensional brittle shear fracturing by tensile crack interaction p64

David Healy, Richard R. Jones and Robert E. Holdsworth

doi:10.1038/nature04346


Phosphonate utilization by the globally important marine diazotroph Trichodesmium p68

S. T. Dyhrman, P. D. Chappell, S. T. Haley, J. W. Moffett, E. D. Orchard, J. B. Waterbury and E. A. Webb

doi:10.1038/nature04203

See also: Editor's summary | News and Views by Sañudo-Wilhelmy


Computer optimization of a minimal biped model discovers walking and running p72

Manoj Srinivasan and Andy Ruina

doi:10.1038/nature04113

See also: Editor's summary


Complex social behaviour derived from maternal reproductive traits p76

Gro V. Amdam, Angela Csondes, M. Kim Fondrk and Robert E. Page, Jr

doi:10.1038/nature04340

See also: Editor's summary


Rapid developmental switch in the mechanisms driving early cortical columnar networks p79

Erwan Dupont, Ileana L. Hanganu, Werner Kilb, Silke Hirsch and Heiko J. Luhmann

doi:10.1038/nature04264


Generation of a functional mammary gland from a single stem cell p84

Mark Shackleton, François Vaillant, Kaylene J. Simpson, John Stingl, Gordon K. Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J. Lindeman and Jane E. Visvader

doi:10.1038/nature04372

See also: Editor's summary


An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection p89

Deborah Palliser, Dipanjan Chowdhury, Qing-Yin Wang, Sandra J. Lee, Roderick T. Bronson, David M. Knipe and Judy Lieberman

doi:10.1038/nature04263

See also: Editor's summary


Potentiation of neuroblastoma metastasis by loss of caspase-8 p95

Dwayne G. Stupack, Tal Teitz, Matthew D. Potter, David Mikolon, Peter J. Houghton, Vincent J. Kidd, Jill M. Lahti and David A. Cheresh

doi:10.1038/nature04323

See also: Editor's summary


Mechanochemical analysis of DNA gyrase using rotor bead tracking p100

Jeff Gore, Zev Bryant, Michael D. Stone, Marcelo Nöllmann, Nicholas R. Cozzarelli and Carlos Bustamante

doi:10.1038/nature04319


RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP p105

Sophie Dumont, Wei Cheng, Victor Serebrov, Rudolf K. Beran, Ignacio Tinoco, Jr, Anna Marie Pyle and Carlos Bustamante

doi:10.1038/nature04331


Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy p109

Florian Garczarek and Klaus Gerwert

doi:10.1038/nature04231


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Naturejobs

Prospect

A plan for the future p113

Help on steering your career.

Paul Smaglik

doi:10.1038/nj7072-113a


Highlights

Highlight: The National Institutes of Health

doi:10.1038/nj0107


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Futures

Gathering of the clans p116

Get in touch with your past.

Reinaldo José Lopes

doi:10.1038/439116a


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