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From the following article:

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

Deborah Palliser, Dipanjan Chowdhury, Qing-Yin Wang, Sandra J. Lee, Roderick T. Bronson, David M. Knipe and Judy Lieberman

Nature 439, 89-94 (5 January 2006)

doi:10.1038/nature04263

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Figure 1

siRNAs administered intravaginally are efficiently taken up by vaginal tissue and durably silence endogenous EGFP expression.

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Figure 2

siRNAs targeting HSV-2 reduce viral replication.

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Figure 3

siRNAs protect mice from lethal HSV-2 infection.

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Figure 4

Topical lipid-complexed siRNAs do not activate inflammation or interferon-responsive genes.

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