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Nature 438, 1090-1091 (22 December 2005) | doi:10.1038/4381090a; Published online 21 December 2005
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Molecular biology: Antagonizing the neighbours
Joel C. Eissenberg1 & Sarah C. R. Elgin2
Abstract
Nucleosomes bundle up the DNA in a cell's nucleus, wrapping it around a complex of histone proteins. Studies of histone modifications and the proteins that bind to them reveal a mechanism that may control this packing.
Crack open any cell nucleus and look inside: you'll see what look like beads on a string. The beads are nucleosomes, small protein complexes that help to package the DNA (the strings) into the cramped confines of the nucleus.
- Joel C. Eissenberg is in the Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA.
Email: eissenjc@slu.edu - Sarah C. R. Elgin is in the Department of Biology, Washington University, St Louis, Missouri 63130, USA.
Email: selgin@biology.wustl.edu
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