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Volume 438 Issue 7071, 22 December 2005

Editorial

  • The end of 2005 was supposed to mark the achievement of a critical goal in the treatment of HIV in poor countries. The goal hasn't been met, but it is now within sight.

    Editorial

    Advertisement

  • Given Japan's strong scientific record, the country has a badly flawed research evaluation system.

    Editorial
  • A prestigious research agency should have thought twice before attaching its name to a diet book.

    Editorial
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Research Highlights

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News

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News in Brief

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2005 Gallery

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News Feature

  • In the first of three Features looking at aspects of alcohol, Siëlle Gramser discovers how yeast first opened the floodgates of intoxication.

    • Siëlle Gramser
    News Feature
  • A decade ago, the tequila industry was pummelled by plant diseases. Rex Dalton meets the scientists working to keep the blue agave diverse enough to survive.

    • Rex Dalton
    News Feature
  • Winemakers in the United States are increasingly calling on the services of geologists to help refine their products. Alexandra Witze meets the scientists who are treading a path to the past.

    • Alexandra Witze
    News Feature
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Business

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Correspondence

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Commentary

  • For the past half-century, biologists have been uncovering details of countless molecular events. Linking these data to dynamic models requires new software and data standards, argue Marvin Cassman and his colleagues.

    • Marvin Cassman
    Commentary
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Books & Arts

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Essay

  • String theory may provide the best clues yet about how to obtain a unified theory that describes all the laws of nature, but do we even understand what string theory is?

    • Edward Witten
    Essay
  • When Subrahmanyan Chandrasekhar asked in his twenties, ‘What happens to a massive star when it runs out of fuel?’ he had little idea that it would take a generation of astronomers to find the answer.

    • Freeman Dyson
    Essay
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News & Views

  • Information is pouring in about Mars. These are thrilling times for those who are proposing — and challenging — ideas about the chemical evolution of the planet and its potential for having harboured life.

    • Mark A. Bullock
    News & Views
  • Nucleosomes bundle up the DNA in a cell's nucleus, wrapping it around a complex of histone proteins. Studies of histone modifications and the proteins that bind to them reveal a mechanism that may control this packing.

    • Joel C. Eissenberg
    • Sarah C. R. Elgin
    News & Views
  • By changing the composition of Earth's atmosphere, human activity has both a warming and a cooling effect on the planet. According to new calculations, that latter influence is large, but it is likely to be declining.

    • Jim Coakley
    News & Views
  • Three species of Aspergillus fungi are the latest organisms to have their genome sequenced. Comparison of the genomes sheds light on, among other things, what endows them with pathogenic or beneficial features.

    • André Goffeau
    News & Views
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Brief Communication

  • These Arctic animals abandon their daily rhythms when it is dark all day or light all night.

    • Bob E. H. van Oort
    • Nicholas J. C. Tyler
    • Karl-Arne Stokkan
    Brief Communication
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Review Article

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Article

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Letter

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Prospects

  • Ways to help justify conference travel.

    • Paul Smaglik
    Prospects
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Futures

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Authors

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Brief Communications Arising

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