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Nature 438, 967-974 (15 December 2005) | doi:10.1038/nature04483; Published online 14 December 2005
Review Article Angiogenesis as a therapeutic target
Napoleone Ferrara1 & Robert S. Kerbel2
Abstract
Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of vascular morphogenesis is needed first.
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