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Nature 438, 932-936 (15 December 2005) | doi:10.1038/nature04478; Published online 14 December 2005

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Review article Angiogenesis in life, disease and medicine

Peter Carmeliet1

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The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.

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