Supplementary information
From the following article:
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii and David Lyden
Nature 438, 820-827 (8 December 2005)
doi:10.1038/nature04186
Supplementary Figure 1
Tumour and VEGFR2+ cells arrive after VEGFR1+ HPCs.
Supplementary Figure 2
VEGFR1 antibody inhibits metastasis in B16 tumours.
Supplementary Figure 3
Inhibition of VLA-4 and MMP-9 inhibits metastasis. B16 melanoma induces fibronectin expression in the lung.
Supplementary Figure 4
Bone marrow-derived VEGFR1+ cells attract tumour cells.
Supplemental Figure 5
Tumours vary in their chemokine profile and fibronectin expression pattern.
Supplementary Table 1
Id3 deficient mice have decreased mobilization of CD11b+ VEGFR1+ hematopoietic progenitors.
Supplementary Methods
Additional details of the methods used in this study.
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