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Editorials

Unapproved tests on a chip p711

Prenatal genetic tests can now check for abnormalities in developing fetuses, but there is still no regulatory framework for them in the United States.

doi:10.1038/438711a


Launching a business p711

There's little evidence that commercial approaches can radically reduce the cost of getting into space.

doi:10.1038/438711b


Enough, already p712

No convincing case has been made for increasing the amount of plutonium held at a Californian lab.

doi:10.1038/438712a


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Research Highlights

Research highlights p714

doi:10.1038/438714a


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News

UK animal labs still under siege p716

Activists maintain pressure as building of Oxford lab resumes.

Tom Simonite and Jim Giles

doi:10.1038/438716a


Animal-rights militancy exported to US and Europe p717

Rise in extremist activity abroad 'aided by British expertise'.

Emma Marris and Tom Simonite

doi:10.1038/438717a


TV show gives research lobbyist a rat's-eye view of laboratory life p717

Pro-animal researcher runs the gauntlet of tests.

doi:10.1038/438717b


Sidelines p718

doi:10.1038/438718a


TV tests call into question cloner's stem-cell success p718

Korean star faces challenges over data.

David Cyranoski

doi:10.1038/438718b


Avian flu centre put under threat of closure p719

Indonesian authorities halt research at frontline station.

Declan Butler

doi:10.1038/438719a


Climate talks edge towards twin-track future p721

UN convention could complement Kyoto Protocol.

Amanda Haag

doi:10.1038/438721a


Prospect of stricter timekeeping alarms US biologists p721

Hackles are raised over revamped guidelines.

Emma Marris

doi:10.1038/438721b


German hostage was saving Iraq digs p722

Kidnapped archaeologist fought against looting.

Andreas von Bubnoff

doi:10.1038/438722a


Cowrie study strikes a blow for traditional taxonomy p722

DNA barcoding fails identification test.

Erika Check

doi:10.1038/438722b


Chairman explains Europe's research council p723

doi:10.1038/438723a


News in brief p724

doi:10.1038/438724a


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News Features

Nonsense mutations: Running the red light p726

A trial drug encourages cells to ignore the signs that stop them making faulty proteins. Sound dangerous? Claire Ainsworth discovers that it could be a cure for genetic disease.

doi:10.1038/438726a

See also: Editor's summary


Neutron science: Back on track? p730

Next June, a $1.4-billion neutron-scattering facility will come online in the United States. Karen Fox finds out whether this machine really can breathe fresh life into the ageing Tennessee lab that is its home.

doi:10.1038/438730a


Fetal genetic testing: Screen test p733

A new technique could allow doctors to spot hundreds of potential genetic problems in unborn babies. But is it too soon to put it to use? Erika Check finds out.

doi:10.1038/438733a


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Business

Internet star shoots for a rocket revolution p736

A newcomer to the space arena claims that his start-up launch company can buck the trend of commercial failures. Tony Reichhardt reports.

Tony Reichhardt

doi:10.1038/438736a


In brief p737

doi:10.1038/438737a


Market Watch p737

doi:10.1038/438737b


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Correspondence

Supplementary data need to be kept in public repositories p738

Carlos Santos, Judith Blake and David J. States

doi:10.1038/438738a


Turkish science needs more than membership of the EU p738

Mehmet Somel

doi:10.1038/438738b


Flu virus will not be sent in the regular US mail p738

Julie Louise Gerberding

doi:10.1038/438738c


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Books and Arts

Physics ain't what it used to be p739

Science is venturing into areas where experimental verification simply isn't possible.

George Ellis reviews The Cosmic Landscape: String Theory and the Illusion of Intelligent Design

doi:10.1038/438739a


Pet project p740

Stephen J. O'Brien reviews The Dog and Its Genome

doi:10.1038/438740a

See also: Editor's summary


On top of the world p741

doi:10.1038/438741a


Exhibition: A close look at Darwin p741

Alan Packer reviews Darwin

doi:10.1038/438741b


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Essay

Concept

The message of the quantum p743

Einstein challenged physics to describe "the real factual situation". But an understanding of the very concepts that he criticized a century ago may provide the best clues yet about reality 'out there'.

Anton Zeilinger

doi:10.1038/438743a


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News and Views

Genomics: The dog has its day p745

Domestication and selective breeding have transformed wolves into the diversity of dogs we see today. The sequence of the genome of one breed adds to our understanding of mammalian biology and genome evolution.

Hans Ellegren

doi:10.1038/438745a

See also: Editor's summary


Water: Ins and outs of ice nucleation p746

Laboratory experiments point to a mechanism by which ice forms from supercooled water with surprising alacrity. Such a mechanism may help to explain ice formation in the atmosphere under certain conditions.

Srikanth Sastry

doi:10.1038/438746a


Cell biology: Relays at the membrane p747

The Wnt signalling pathway is a major route by which the cell conveys information from its exterior to the nucleus. A gap in the sequence of signalling proteins has now been filled.

Roel Nusse

doi:10.1038/438747a


Quantum information: Remember that photon p749

Storing single photons in atomic memories, and releasing them at a later time, is a required step on the way to quantum repeaters and long-distance quantum cryptography networks. This step has now been taken.

Philippe Grangier

doi:10.1038/438749a

See also: Editor's summary


50 & 100 years ago p750

doi:10.1038/438750a


Cancer biology: Emissaries set up new sites p750

The capacity of tumours to spread to other organs is one of their most dangerous attributes. A study of how cancer cells settle in new places shows that they send out envoys to prepare the ground for them.

Patricia S. Steeg

doi:10.1038/438750b

See also: Editor's summary


Obituary: Alastair Cameron (1925–2005) p752

Astrophysicist and planetary scientist.

John Wood

doi:10.1038/438752a


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Brief Communications

Biomechanics: No force limit on greyhound sprint speed p753

Unlike human athletes, these dogs do not need to slow down when racing round a tight bend.

James R. Usherwood and Alan M. Wilson

doi:10.1038/438753a

See also: Editor's summary


Astrophysics: Is a doomsday catastrophe likely? p754

Max Tegmark and Nick Bostrom

doi:10.1038/438754a


Corrigendum p754

doi:10.1038/438754b


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Brief Communications Arising

Planetary science: Are there active glaciers on Mars? pE9

Alan R. Gillespie, David R. Montgomery and Amit Mushkin

doi:10.1038/nature04357

See also: Editor's summary


Planetary science: Are there active glaciers on Mars? (Reply) pE10

J. W. Head, G. Neukum, R. Jaumann, H. Hiesinger, E. Hauber, M. Carr, P. Masson, B. Foing, H. Hoffmann, M. Kreslavsky, S. Werner, S. Milkovich, S. van Gasselt and The HRSC Co-Investigator Team

doi:10.1038/nature04358


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Huygens News & Views

Planetary science: Huygens rediscovers Titan p756

The first analyses of data sent by the Huygens probe from Saturn's largest moon Titan are flooding in. They paint a picture of a 'Peter Pan' world — potentially like Earth, but with its development frozen at an early stage.

Tobias Owen

doi:10.1038/438756a

See also: Editor's summary


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Huygens Articles

An overview of the descent and landing of the Huygens probe on Titan p758

Jean-Pierre Lebreton, Olivier Witasse, Claudio Sollazzo, Thierry Blancquaert, Patrice Couzin, Anne-Marie Schipper, Jeremy B. Jones, Dennis L. Matson, Leonid I. Gurvits, David H. Atkinson, Bobby Kazeminejad and Miguel Pérez-Ayúcar

doi:10.1038/nature04347

See also: Editor's summary | Authors


Rain, winds and haze during the Huygens probe's descent to Titan's surface p765

M. G. Tomasko, B. Archinal, T. Becker, B. Bézard, M. Bushroe, M. Combes, D. Cook, A. Coustenis, C. de Bergh, L. E. Dafoe, L. Doose, S. Douté, A. Eibl, S. Engel, F. Gliem, B. Grieger, K. Holso, E. Howington-Kraus, E. Karkoschka, H. U. Keller, R. Kirk, R. Kramm, M. Küppers, P. Lanagan, E. Lellouch, M. Lemmon, J. Lunine, E. McFarlane, J. Moores, G. M. Prout, B. Rizk, M. Rosiek, P. Rueffer, S. E. Schröder, B. Schmitt, C. See, P. Smith, L. Soderblom, N. Thomas and R. West

doi:10.1038/nature04126

See also: Editor's summary | Authors


The abundances of constituents of Titan's atmosphere from the GCMS instrument on the Huygens probe p779

H. B. Niemann, S. K. Atreya, S. J. Bauer, G. R. Carignan, J. E. Demick, R. L. Frost, D. Gautier, J. A. Haberman, D. N. Harpold, D. M. Hunten, G. Israel, J. I. Lunine, W. T. Kasprzak, T. C. Owen, M. Paulkovich, F. Raulin, E. Raaen and S. H. Way

doi:10.1038/nature04122

See also: Editor's summary | Authors


In situ measurements of the physical characteristics of Titan's environment p785

M. Fulchignoni, F. Ferri, F. Angrilli, A. J. Ball, A. Bar-Nun, M. A. Barucci, C. Bettanini, G. Bianchini, W. Borucki, G. Colombatti, M. Coradini, A. Coustenis, S. Debei, P. Falkner, G. Fanti, E. Flamini, V. Gaborit, R. Grard, M. Hamelin, A. M. Harri, B. Hathi, I. Jernej, M. R. Leese, A. Lehto, P. F. Lion Stoppato, J. J. López-Moreno, T. Mäkinen, J. A. M. McDonnell, C. P. McKay, G. Molina-Cuberos, F. M. Neubauer, V. Pirronello, R. Rodrigo, B. Saggin, K. Schwingenschuh, A. Seiff, F. Simões, H. Svedhem, T. Tokano, M. C. Towner, R. Trautner, P. Withers and J. C. Zarnecki

doi:10.1038/nature04314

See also: Editor's summary | Authors


A soft solid surface on Titan as revealed by the Huygens Surface Science Package p792

John C. Zarnecki, Mark R. Leese, Brijen Hathi, Andrew J. Ball, Axel Hagermann, Martin C. Towner, Ralph D. Lorenz, J. Anthony M. McDonnell, Simon F. Green, Manish R. Patel, Timothy J. Ringrose, Philip D. Rosenberg, Karl R. Atkinson, Mark D. Paton, Marek Banaszkiewicz, Benton C. Clark, Francesca Ferri, Marcello Fulchignoni, Nadeem A. L. Ghafoor, Günter Kargl, Håkan Svedhem, John Delderfield, Manuel Grande, David J. Parker, Peter G. Challenor and John E. Geake

doi:10.1038/nature04211

See also: Editor's summary | Authors


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Huygens Letters

Complex organic matter in Titan's atmospheric aerosols from in situ pyrolysis and analysis p796

G. Israël, C. Szopa, F. Raulin, M. Cabane, H. B. Niemann, S. K. Atreya, S. J. Bauer, J.-F. Brun, E. Chassefière, P. Coll, E. Condé, D. Coscia, A. Hauchecorne, P. Millian, M.-J. Nguyen, T. Owen, W. Riedler, R. E. Samuelson, J.-M. Siguier, M. Steller, R. Sternberg and C. Vidal-Madjar

doi:10.1038/nature04349

See also: Editor's summary | Authors


The vertical profile of winds on Titan p800

M. K. Bird, M. Allison, S. W. Asmar, D. H. Atkinson, I. M. Avruch, R. Dutta-Roy, Y. Dzierma, P. Edenhofer, W. M. Folkner, L. I. Gurvits, D. V. Johnston, D. Plettemeier, S. V. Pogrebenko, R. A. Preston and G. L. Tyler

doi:10.1038/nature04060

See also: Editor's summary | Authors


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Articles

Genome sequence, comparative analysis and haplotype structure of the domestic dog p803

Kerstin Lindblad-Toh, Claire M Wade, Tarjei S. Mikkelsen, Elinor K. Karlsson, David B. Jaffe, Michael Kamal, Michele Clamp, Jean L. Chang, Edward J. Kulbokas, III, Michael C. Zody, Evan Mauceli, Xiaohui Xie, Matthew Breen, Robert K. Wayne, Elaine A. Ostrander, Chris P. Ponting, Francis Galibert, Douglas R. Smith, Pieter J. deJong, Ewen Kirkness, Pablo Alvarez, Tara Biagi, William Brockman, Jonathan Butler, Chee-Wye Chin, April Cook, James Cuff, Mark J. Daly, David DeCaprio, Sante Gnerre, Manfred Grabherr, Manolis Kellis, Michael Kleber, Carolyne Bardeleben, Leo Goodstadt, Andreas Heger, Christophe Hitte, Lisa Kim, Klaus-Peter Koepfli, Heidi G. Parker, John P. Pollinger, Stephen M. J. Searle, Nathan B. Sutter, Rachael Thomas and Caleb Webber, Broad Sequencing Platform members and Eric S. Lander

doi:10.1038/nature04338

See also: Editor's summary | News and Views by Ellegren


VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche p820

Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii and David Lyden

doi:10.1038/nature04186

See also: Editor's summary | News and Views by Steeg


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Letters

Measurement-induced entanglement for excitation stored in remote atomic ensembles p828

C. W. Chou, H. de Riedmatten, D. Felinto, S. V. Polyakov, S. J. van Enk and H. J. Kimble

doi:10.1038/nature04353

See also: Editor's summary


Storage and retrieval of single photons transmitted between remote quantum memories p833

T. Chanelière, D. N. Matsukevich, S. D. Jenkins, S.-Y. Lan, T. A. B. Kennedy and A. Kuzmich

doi:10.1038/nature04315

See also: Editor's summary | News and Views by Grangier


Electromagnetically induced transparency with tunable single-photon pulses p837

M. D. Eisaman, A. André, F. Massou, M. Fleischhauer, A. S. Zibrov and M. D. Lukin

doi:10.1038/nature04327

See also: Editor's summary | News and Views by Grangier


A lithospheric instability origin for Columbia River flood basalts and Wallowa Mountains uplift in northeast Oregon p842

T. C. Hales, D. L. Abt, E. D. Humphreys and J. J. Roering

doi:10.1038/nature04313


Determinants of woody cover in African savannas p846

Mahesh Sankaran, Niall P. Hanan, Robert J. Scholes, Jayashree Ratnam, David J. Augustine, Brian S. Cade, Jacques Gignoux, Steven I. Higgins, Xavier Le Roux, Fulco Ludwig, Jonas Ardo, Feetham Banyikwa, Andries Bronn, Gabriela Bucini, Kelly K. Caylor, Michael B. Coughenour, Alioune Diouf, Wellington Ekaya, Christie J. Feral, Edmund C. February, Peter G. H. Frost, Pierre Hiernaux, Halszka Hrabar, Kristine L. Metzger, Herbert H. T. Prins, Susan Ringrose, William Sea, Jörg Tews, Jeff Worden and Nick Zambatis

doi:10.1038/nature04070

See also: Editor's summary | Authors


The phylogenetic position of the 'giant deer' Megaloceros giganteus p850

A. M. Lister, C. J. Edwards, D. A. W. Nock, M. Bunce, I. A. van Pijlen, D. G. Bradley, M. G. Thomas and I. Barnes

doi:10.1038/nature04134

See also: Editor's summary


Morphine reward in dopamine-deficient mice p854

Thomas S. Hnasko, Bethany N. Sotak and Richard D. Palmiter

doi:10.1038/nature04172

See also: Editor's summary | Authors


BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration p858

Matthew W. Grogg, Mindy K. Call, Mitsumasa Okamoto, M. Natalia Vergara, Katia Del Rio-Tsonis and Panagiotis A. Tsonis

doi:10.1038/nature04175


A colonization factor links Vibrio cholerae environmental survival and human infection p863

Thomas J. Kirn, Brooke A. Jude and Ronald K. Taylor

doi:10.1038/nature04249

See also: Editor's summary


Casein kinase 1 bold gamma couples Wnt receptor activation to cytoplasmic signal transduction p867

Gary Davidson, Wei Wu, Jinlong Shen, Josipa Bilic, Ursula Fenger, Peter Stannek, Andrei Glinka and Christof Niehrs

doi:10.1038/nature04170

See also: News and Views by Nusse


A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation p873

Xin Zeng, Keiko Tamai, Brad Doble, Shitao Li, He Huang, Raymond Habas, Heidi Okamura, Jim Woodgett and Xi He

doi:10.1038/nature04185

See also: News and Views by Nusse


The importance of sequence diversity in the aggregation and evolution of proteins p878

Caroline F. Wright, Sarah A. Teichmann, Jane Clarke and Christopher M. Dobson

doi:10.1038/nature04195

See also: Editor's summary


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Naturejobs

Prospect

Seeking soft skills p883

Career panel points to off-the-bench skills.

Paul Smaglik

doi:10.1038/nj7069-883a


Postdocs and Students

Toddlers, teens and test tubes p884

Young careers and young families can leave investigators feeling stretched. Kendall Powell finds out how to keep the two from clashing.

Kendall Powell

doi:10.1038/nj7069-884a


Career Views

Graduate journal - Year-End Review: A change of outlook

From tough decisions and unexpected complications come new perspectives and opportunities.

Anne Margaret Lee

doi:10.1038/nj0101


Graduate journal - Year-End Review: Evaluating a career decision

A switch from medicine to research brings reflections on the value of medical education, the freedom of science and the constants that help one survive graduate school.

Tobias Langenhan

doi:10.1038/nj0102


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Futures

Transport of delight p888

The highs and lows of commuting.

Roland Denison

doi:10.1038/438888a


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