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From the following article:

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii & David Lyden

Nature 438, 820-827(8 December 2005)

doi:10.1038/nature04186

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Figure 1

Bone marrow-derived cells form the pre-metastatic niche.

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Figure 2

Pre-metastatic clusters are comprised of VEGFR1+ haematopoietic progenitors.

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Figure 3

Expression of VEGFR1 in pre-metastatic human tissue.

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Figure 4

Inhibition of homing of bone marrow cells prevents metastasis.

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Figure 5

The VLA-4/fibronectin pathway mediates cluster formation.

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Figure 6

Redirection of LLC metastases to atypical sites.

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