Editor's Summary

8 December 2005

The Dog Genome


The genome of the domestic dog is arguably the most interesting of the 5,500 species of mammals on Earth, genetically speaking. The remarkable diversity between breeds, created by a brief period of intensive human-driven selection for behavioural and physical traits, means that its sequence contains critical clues to understanding genome evolution and organization, and predisposition to disease. In this issue, Lindblad-Toh et al. publish the high-quality draft sequence of the dog genome – that of female boxer Tasha – and outline some of the genetic differences between breeds. Comparative analysis with humans and rodents provides a general perspective on gene and genome evolution. And see Books and Arts for a review of the book of the genome. (Cover art: Bang Wong, Broad Institute of MIT and Harvard. Photos: Alison Ruhe, University of California, Davis. Watson and Crick: A Barrington Brown/SPL). See also Genome Research

Books and ArtsPet project

doi:10.1038/438740a

News and ViewsGenomics: The dog has its day

Domestication and selective breeding have transformed wolves into the diversity of dogs we see today. The sequence of the genome of one breed adds to our understanding of mammalian biology and genome evolution.

Hans Ellegren

doi:10.1038/438745a

ArticleGenome sequence, comparative analysis and haplotype structure of the domestic dog

Kerstin Lindblad-Toh, Claire M Wade, Tarjei S. Mikkelsen, Elinor K. Karlsson, David B. Jaffe, Michael Kamal, Michele Clamp, Jean L. Chang, Edward J. Kulbokas, III, Michael C. Zody, Evan Mauceli, Xiaohui Xie, Matthew Breen, Robert K. Wayne, Elaine A. Ostrander, Chris P. Ponting, Francis Galibert, Douglas R. Smith, Pieter J. deJong, Ewen Kirkness, Pablo Alvarez, Tara Biagi, William Brockman, Jonathan Butler, Chee-Wye Chin, April Cook, James Cuff, Mark J. Daly, David DeCaprio, Sante Gnerre, Manfred Grabherr, Manolis Kellis, Michael Kleber, Carolyne Bardeleben, Leo Goodstadt, Andreas Heger, Christophe Hitte, Lisa Kim, Klaus-Peter Koepfli, Heidi G. Parker, John P. Pollinger, Stephen M. J. Searle, Nathan B. Sutter, Rachael Thomas, Caleb WebberBroad Sequencing Platform membersJennifer Baldwin, Adal Abebe, Amr Abouelleil, Lynne Aftuck, Mostafa Ait-zahra, Tyler Aldredge, Nicole Allen, Peter An, Scott Anderson, Claudel Antoine, Harindra Arachchi, Ali Aslam, Laura Ayotte, Pasang Bachantsang, Andrew Barry, Tashi Bayul, Mostafa Benamara, Aaron Berlin, Daniel Bessette, Berta Blitshteyn, Toby Bloom, Jason Blye, Leonid Boguslavskiy, Claude Bonnet, Boris Boukhgalter, Adam Brown, Patrick Cahill, Nadia Calixte, Jody Camarata, Yama Cheshatsang, Jeffrey Chu, Mieke Citroen, Alville Collymore, Patrick Cooke, Tenzin Dawoe, Riza Daza, Karin Decktor, Stuart DeGray, Norbu Dhargay, Kimberly Dooley, Kathleen Dooley, Passang Dorje, Kunsang Dorjee, Lester Dorris, Noah Duffey, Alan Dupes, Osebhajajeme Egbiremolen, Richard Elong, Jill Falk, Abderrahim Farina, Susan Faro, Diallo Ferguson, Patricia Ferreira, Sheila Fisher, Mike FitzGerald, Karen Foley, Chelsea Foley, Alicia Franke, Dennis Friedrich, Diane Gage, Manuel Garber, Gary Gearin, Georgia Giannoukos, Tina Goode, Audra Goyette, Joseph Graham, Edward Grandbois, Kunsang Gyaltsen, Nabil Hafez, Daniel Hagopian, Birhane Hagos, Jennifer Hall, Claire Healy, Ryan Hegarty, Tracey Honan, Andrea Horn, Nathan Houde, Leanne Hughes, Leigh Hunnicutt, M. Husby, Benjamin Jester, Charlien Jones, Asha Kamat, Ben Kanga, Cristyn Kells, Dmitry Khazanovich, Alix Chinh Kieu, Peter Kisner, Mayank Kumar, Krista Lance, Thomas Landers, Marcia Lara, William Lee, Jean-Pierre Leger, Niall Lennon, Lisa Leuper, Sarah LeVine, Jinlei Liu, Xiaohong Liu, Yeshi Lokyitsang, Tashi Lokyitsang, Annie Lui, Jan Macdonald, John Major, Richard Marabella, Kebede Maru, Charles Matthews, Susan McDonough, Teena Mehta, James Meldrim, Alexandre Melnikov, Louis Meneus, Atanas Mihalev, Tanya Mihova, Karen Miller, Rachel Mittelman, Valentine Mlenga, Leonidas Mulrain, Glen Munson, Adam Navidi, Jerome Naylor, Tuyen Nguyen, Nga Nguyen, Cindy Nguyen, Thu Nguyen, Robert Nicol, Nyima Norbu, Choe Norbu, Nathaniel Novod, Tenchoe Nyima, Peter Olandt, Barry O'Neill, Keith O'Neill, Sahal Osman, Lucien Oyono, Christopher Patti, Danielle Perrin, Pema Phunkhang, Fritz Pierre, Margaret Priest, Anthony Rachupka, Sujaa Raghuraman, Rayale Rameau, Verneda Ray, Christina Raymond, Filip Rege, Cecil Rise, Julie Rogers, Peter Rogov, Julie Sahalie, Sampath Settipalli, Theodore Sharpe, Terrance Shea, Mechele Sheehan, Ngawang Sherpa, Jianying Shi, Diana Shih, Jessie Sloan, Cherylyn Smith, Todd Sparrow, John Stalker, Nicole Stange-Thomann, Sharon Stavropoulos, Catherine Stone, Sabrina Stone, Sean Sykes, Pierre Tchuinga, Pema Tenzing, Senait Tesfaye, Dawa Thoulutsang, Yama Thoulutsang, Kerri Topham, Ira Topping, Tsamla Tsamla, Helen Vassiliev, Vijay Venkataraman, Andy Vo, Tsering Wangchuk, Tsering Wangdi, Michael Weiand, Jane Wilkinson, Adam Wilson, Shailendra Yadav, Shuli Yang, Xiaoping Yang, Geneva Young, Qing Yu, Joanne Zainoun, Lisa Zembek and Andrew Zimmer and Eric S. Lander

doi:10.1038/nature04338

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