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Nature 438, 578-580 (1 December 2005) | doi:10.1038/nature04394; Published online 30 November 2005
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Introduction Membranes are more mosaic than fluid
Donald M. Engelman1
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Abstract
The wealth of new data on membrane protein structures and functions is changing our general view of membrane architecture. Some of the key themes that are emerging are that membranes are patchy, with segregated regions of structure and function, that lipid regions vary in thickness and composition, and that crowding and ectodomains limit exposure of lipid to the adjacent aqueous regions.
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