Paul R. Renne, Joshua M. Feinberg, Michael R. Waters, Joaquin Arroyo-Cabrales, Patricia Ochoa-Castillo, Mario Perez-Campaand Kim B. Knight
doi:10.1038/nature04425
Table of contents
Volume 438 Number 7068 ppE7-710
In this issue (1 December 2005)
Also this week
(this content only available online) indicates content that is available online only
Top of page
Brief Communications
Top of pageBrief Communications Arising
Geochronology: Age of Mexican ash with alleged 'footprints' pE7
Top of page
Authors
Making the paper pxv
Statistical analysis provides a fresh perspective on asthma.
Urs Frey
doi:10.1038/7068xva
Abstractions pxv
doi:10.1038/7068xvb
Quantified: Austria pxv
doi:10.1038/7068xvc
Top of page
Editorials
Let data speak to data p531
Web tools now allow data sharing and informal debate to take place alongside published papers. But to take full advantage, scientists must embrace a culture of sharing and rethink their vision of databases.
doi:10.1038/438531a
Life at the edge p531
Successes in structural studies of membrane proteins deserve to be celebrated.
doi:10.1038/438531b
Stem-cell probe needed p532
South Korea would benefit from investigating what went wrong in its leading stem-cell lab.
doi:10.1038/438532a
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News
Clone star admits lies over eggs p536
Calls for fuller investigation as national hero confesses.
David Cyranoskiand Erika Check
doi:10.1038/438536a
Antarctic ice puts climate predictions to the test p536
Frozen record of the past reveals models' shortcomings.
Michael Hopkin
doi:10.1038/438536b
Titan: tapping the flood of data p538
The first analyses of the Huygens mission to Titan are published this week. Mark Peplow charts the satellite's transition from fogbound moon to familiar landscape, and finds out why scientists long to return.
doi:10.1038/438538a
Rocky future predicted for labs that rely on postdocs p541
Dependence on foreign expertise threatens US research.
Geoff Brumfiel
doi:10.1038/438541a
Sidelines p541
doi:10.1038/438541b
Europe's cash crisis puts space plans under threat p542
ESA budget review puts mission to Mercury in jeopardy
Jenny Hogan
doi:10.1038/438542a
Hayabusa ready to head home with asteroid sample p542
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News Features
Science in the web age: The expanding electronic universe p547
Science in the web age: Joint efforts p548
At its best, academia is a marketplace of ideas. But many scientists are reluctant to embrace the latest web tools that would allow them to communicate their ideas in new ways, says Declan Butler.
Declan Butler
doi:10.1038/438548a
Science in the web age: The real death of print p550
Despite clashes with publishers over copyright, Google's plan to make millions of books available online is turning the tide for efforts to digitize the world's literature. Andreas von Bubnoff tracks the demise of the printed page.
Andreas von Bubnoff
doi:10.1038/438550a
Science in the web age: Start your engines p554
Google has launched another challenge to commercial search services — this time aimed at scientists. But is the new engine running as smoothly as its fans hope? Jim Giles investigates.
Jim Giles
doi:10.1038/438554a
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Business
Swiss star finds it tough at the top p557
Serono is calling in outside advice. Colin Macilwain investigates the future of Europe's leading biotech firm.
doi:10.1038/438557a
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Correspondence
Automated grading of research performance clearly fails to measure up p559
Animal-rights zealots put wildlife welfare at risk p559
Evaluation bias hits women who aren't twice as good p559
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Books and Arts
Different class p561
The 'big three' universities in the United States are upholding a long tradition of élitism.
doi:10.1038/438561a
Cultural reflections p562
doi:10.1038/438562a
An inside view of the Universe p563
doi:10.1038/438563a
Science in culture: Dying for a drink p564
Evolution goes backwards in the latest Guinness advertisement.
Martin Kemp
doi:10.1038/438564a
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News and Views
海洋学：速度が落ちた大西洋の熱輸送装置
Oceanography: The Atlantic heat conveyor slows p565
Computer simulations predict that global warming will weaken the ocean circulation that transports heat from the tropics to higher latitudes in the North Atlantic. Such an effect has now been detected.
Detlef Quadfasel
doi:10.1038/438565a
生物物理：組み立てラインを調べる
Biophysics: Assembly line inspection p566
Many of the biochemical events that occur in a cell are performed by huge complexes of proteins and nucleic acids. A cunning approach promises to show how the components convene to make a functioning 'machine'.
Sarah A. Woodson
doi:10.1038/438566a
50 & 100 years ago p567
doi:10.1038/438567a
細胞生物学：脂質まみれのタンパク質
Cell biology: A greasy grip p569
How do the lipids and proteins of the cell membrane interact to create a functioning barrier for the cell? A high-resolution structure of a membrane protein reveals intimate contacts with its lipid neighbours.
Anthony G. Lee
doi:10.1038/438569a
惑星科学：火星の歴史を語る土壌成分
Planetary science: Clays in the history of Mars p570
The stream of revelations from Mars continues. The latest news — the discovery of clays in ancient terrains — helps to fill in the picture of the past existence of liquid water on the planet's surface.
Horton Newsom
doi:10.1038/438570a
細胞生物学：エンドサイトーシスを起こすもの
Cell biology: Protein choreography p571
Just under the cell surface, proteins engage in an intricate ballet to drive a transport process called endocytosis. Much is known about the individual dancers, but now the choreography is revealed.
Mara C. Duncanand Gregory S. Payne
doi:10.1038/438571a
Correction p573
doi:10.1038/438573a
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Brief Communications
Fruit bats as reservoirs of Ebola virus p575
Bat species eaten by people in central Africa show evidence of symptomless Ebola infection.
Eric M. Leroy, Brice Kumulungui, Xavier Pourrut, Pierre Rouquet, Alexandre Hassanin, Philippe Yaba, André Délicat, Janusz T. Paweska, Jean-Paul Gonzalezand Robert Swanepoel
doi:10.1038/438575a
First paragraph | Full Text| PDF (500K) | Supplementary information
Palaeoecology: A gigantic fossil arthropod trackway p576
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Insight: Membrane biology
Insight: Membrane biology -
Insight: Membrane biology
Membrane biology p577
Membranes are more mosaic than fluid p578
Solving the membrane protein folding problem p581
Membrane curvature and mechanisms of dynamic cell membrane remodelling p590
Organelle identity and the signposts for membrane traffic p597
Plasma membrane phosphoinositide organization by protein electrostatics p605
Role of cholesterol and lipid organization in disease p612
Top of page
Articles
宇宙：火星の層状ケイ酸塩と初期の火星の気候との関連
Phyllosilicates on Mars and implications for early martian climate p623
F. Poulet, J.-P. Bibring, J. F. Mustard, A. Gendrin, N. Mangold, Y. Langevin, R. E. Arvidson, B. Gondetand C. GomezThe Omega TeamM. Berthé, J.-P. Bibring, Y. Langevin, S. Erard, O. Forni, A. Gendrin, B. Gondet, N. Manaud, F. Poulet, G. Poulleau, A. Soufflot, M. Combes, P. Drossart, T. Encrenaz, T. Fouchet, R. Melchiorri, G. Bellucci, F. Altieri, V. Formisano, S. Fonti, F. Capaccioni, P. Cerroni, A. Coradini, O. Korablev, V. Kottsov, N. Ignatiev, D. Titov, L. Zasova, N. Mangold, P. Pinet, B. Schmitt, C. Sotin, E. Hauber, H. Hoffmann, R. Jaumann, U. Keller, R. Arvidson, J. Mustardand F. Forget
doi:10.1038/nature04274
生物物理：30Sリボソームサブユニットの集合地形
An assembly landscape for the 30S ribosomal subunit p628
Megan W. T. Talkington, Gary Siuzdakand James R. Williamson
doi:10.1038/nature04261
生物物理：2層に重なった2次元 AQP0結晶における脂質−タンパク質相互作用
Lipid–protein interactions in double-layered two-dimensional AQP0 crystals p633
Tamir Gonen, Yifan Cheng, Piotr Sliz, Yoko Hiroaki, Yoshinori Fujiyoshi, Stephen C. Harrisonand Thomas Walz
doi:10.1038/nature04321
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Letters
物理：6個の原子からなる「シュレーディンガーの猫」状態の生成
Creation of a six-atom 'Schrödinger cat' state p639
D. Leibfried, E. Knill, S. Seidelin, J. Britton, R. B. Blakestad, J. Chiaverini, D. B. Hume, W. M. Itano, J. D. Jost, C. Langer, R. Ozeri, R. Reichleand D. J. Wineland
doi:10.1038/nature04251
物理：捕獲イオンの拡張可能な多粒子もつれ合い
Scalable multiparticle entanglement of trapped ions p643
H. Häffner, W. Hänsel, C. F. Roos, J. Benhelm, D. Chek-al-kar, M. Chwalla, T. Körber, U. D. Rapol, M. Riebe, P. O. Schmidt, C. Becher, O. Gühne, W. Dürand R. Blatt
doi:10.1038/nature04279
物性：ボロンを高濃度ドープした超伝導ダイヤモンドの金属的性質の起源
Origin of the metallic properties of heavily boron-doped superconducting diamond p647
T. Yokoya, T. Nakamura, T. Matsushita, T. Muro, Y. Takano, M. Nagao, T. Takenouchi, H. Kawaradaand T. Oguchi
doi:10.1038/nature04278
化学：無限配位高分子からの化学的に調整可能なコロイド粒子
Chemically tailorable colloidal particles from infinite coordination polymers p651
Moonhyun Ohand Chad A. Mirkin
doi:10.1038/nature04191
海洋：大西洋の南北方向の鉛直循環が北緯25度で減速している
Slowing of the Atlantic meridional overturning circulation at 25° N p655
Harry L. Bryden, Hannah R. Longworthand Stuart A. Cunningham
doi:10.1038/nature04385
生態：熱帯林における高木種の種数ｰ個体数関係と多様性は密度依存性で説明できる
Density dependence explains tree species abundance and diversity in tropical forests p658
Igor Volkov, Jayanth R. Banavar, Fangliang He, Stephen P. Hubbelland Amos Maritan
doi:10.1038/nature04030
脳：マウスの不安を調節するグリオキサラーゼ1とグルタチオンレダクターゼ1
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice p662
Iiris Hovatta, Richard S. Tennant, Robert Helton, Robert A. Marr, Oded Singer, Jeffrey M. Redwine, Julie A. Ellison, Eric E. Schadt, Inder M. Verma, David J. Lockhartand Carrolee Barlow
doi:10.1038/nature04250
医学：気道機能のゆらぎ解析から予測する重症の喘息エピソードのリスク
Risk of severe asthma episodes predicted from fluctuation analysis of airway function p667
Urs Frey, Tanja Brodbeck, Arnab Majumdar, D. Robin Taylor, G. Ian Town, Michael Silvermanand Béla Suki
doi:10.1038/nature04176
発生：マイクロRNA miR-196は四肢発生の際にHoxb8とShhの上流で機能する
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development p671
Eran Hornstein, Jennifer H. Mansfield, Soraya Yekta, Jimmy Kuang-Hsien Hu, Brian D. Harfe, Michael T. McManus, Scott Baskerville, David P. Barteland Clifford J. Tabin
doi:10.1038/nature04138
生化学：エンドフィリンとCtBP/BARSはエンドサイトーシスやゴルジ分裂におけるアシル基転移酵素ではない
Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission p675
Jennifer L. Gallop, P. Jonathan G. Butlerand Harvey T. McMahon
doi:10.1038/nature04136
生化学：酵母のタンパク質リン酸化の包括的解析
Global analysis of protein phosphorylation in yeast p679
Jason Ptacek, Geeta Devgan, Gregory Michaud, Heng Zhu, Xiaowei Zhu, Joseph Fasolo, Hong Guo, Ghil Jona, Ashton Breitkreutz, Richelle Sopko, Rhonda R. McCartney, Martin C. Schmidt, Najma Rachidi, Soo-Jung Lee, Angie S. Mah, Lihao Meng, Michael J. R. Stark, David F. Stern, Claudio De Virgilio, Mike Tyers, Brenda Andrews, Mark Gerstein, Barry Schweitzer, Paul F. Predkiand Michael Snyder
doi:10.1038/nature04187
細胞：「antagomir」を用いたin vivoにおけるマイクロRNAのサイレンシング
Silencing of microRNAs in vivo with 'antagomirs' p685
Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich, Kallanthottathil G. Rajeev, Thomas Tuschl, Muthiah Manoharanand Markus Stoffel
doi:10.1038/nature04303
生化学：APC/CとCBP/p300は協同して転写と細胞周期の進行を調節する
The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression p690
Andrew S. Turnell, Grant S. Stewart, Roger J. A. Grand, Susan M. Rookes, Ashley Martin, Hiroyuki Yamano, Stephen J. Elledgeand Phillip H. Gallimore
doi:10.1038/nature04151
Erratum: Astronomical pacing of methane release in the Early Jurassic period p696
David B. Kemp, Angela L. Coe, Anthony S. Cohenand Lorenz Schwark
doi:10.1038/nature04361
Corrigendum: A network-based analysis of systemic inflammation in humans p696
Steve E. Calvano, Wenzhong Xiao, Daniel R. Richards, Ramon M. Felciano, Henry V. Baker, Raymond J. Cho, Richard O. Chen, Bernard H. Brownstein, J. Perren Cobb, S. Kevin Tschoeke, Carol Miller-Graziano, Lyle L. Moldawer, Michael N. Mindrinos, Ronald W. Davis, Ronald G. Tompkinsand Stephen F. LowryInflammation and Host Response to Injury Large Scale Collaborative Research ProgramPaul E. Bankey, Timothy R. Billiar, David G. Camp, George Casella, Irshad H. Chaudry, Mashkoor A. Choudhry, Charles Cooper, Asit De, Constance Elson, Bradley Freeman, Richard L. Gamelli, Celeste Campbell-Finnerty, Nicole S. Gibran, Douglas L. Hayden, Brian G. Harbrecht, David N. Herndon, Jureta W. Horton, William J. Hubbard, John L. Hunt, Jeffrey Johnson, Matthew B. Klein, James A. Lederer, Tanya Logvinenko, Ronald V. Maier, John A. Mannick, Philip H. Mason, Bruce A. McKinley, Joseph P. Minei, Ernest E. Moore, Frederick A. Moore, Avery B. Nathens, Grant E. O'Keefe, Laurence G. Rahme, Daniel G. Remick, David A. Schoenfeld, Martin G. Schwacha, Michael B. Shapiro, Geoffrey M. Silver, Richard D. Smith, John D. Storey, Mehmet Toner, H. Shaw Warrenand Michael A. West
doi:10.1038/nature04362
Corrigendum: DNA sequence and analysis of human chromosome 18 p696
Chad Nusbaum, Michael C. Zody, Mark L. Borowsky, Michael Kamal, Chinnappa D. Kodira, Todd D. Taylor, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Amr Abouelleil, Nicole R. Allen, Scott Anderson, Toby Bloom, Boris Bugalter, Jonathan Butler, April Cook, David DeCaprio, Reinhard Engels, Manuel Garber, Andreas Gnirke, Nabil Hafez, Jennifer L. Hall, Catherine Hosage Norman, Takehiko Itoh, David B. Jaffe, Yoko Kuroki, Jessica Lehoczky, Annie Lui, Pendexter Macdonald, Evan Mauceli, Tarjei S. Mikkelsen, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Hideki Noguchi, Sinéad B. O'Leary, Keith O'Neill, Bruno Piqani, Cherylyn L. Smith, Jessica A. Talamas, Kerri Topham, Yasushi Totoki, Atsushi Toyoda, Hester M. Wain, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Asao Fujiyama, Masahira Hattori, Bruce W. Birren, Yoshiyuki Sakakiand Eric S. Lander
doi:10.1038/nature04363
Top of page
Technology Features
Cell biology: Ion channels and stem cells p699
Ion channels, stem cells and cell signalling are the focus of intense interest in both cell biology and drug discovery. Pete Moore takes a look at what's on offer for the researcher.
Pete Moore
doi:10.1038/438699a
Cell biology: Maximizing return p699
doi:10.1038/438699b
Cell biology: Stem-cell options p700
doi:10.1038/438700a
Cell biology: Banking on stem cells p701
doi:10.1038/438701a
Cell biology: Signals of disease p702
doi:10.1038/438702a
Cell biology: Table of suppliers p703
doi:10.1038/438703a
Top of page
Careers and Recruitment
Highlights
Naturejobs
ProspectPhysics in crisis? p705
The falling number of physicists in England and Wales needs to be addressed.
Paul Smaglik
doi:10.1038/nj7068-705a
Careers and Recruitment
Thinking outside the cell p706
New tools and technologies are allowing cell biologists to take a more holistic view. To make the most of this, they are teaming up with scientists from other fields. Corie Lok reports.
Corie Lok
doi:10.1038/nj7068-706a
Highlights
Highlight: The National Institutes of Health
doi:10.1038/nj0100
