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Let data speak to data p531

Web tools now allow data sharing and informal debate to take place alongside published papers. But to take full advantage, scientists must embrace a culture of sharing and rethink their vision of databases.


Life at the edge p531

Successes in structural studies of membrane proteins deserve to be celebrated.


Stem-cell probe needed p532

South Korea would benefit from investigating what went wrong in its leading stem-cell lab.



Research Highlights

Research highlights p534




Clone star admits lies over eggs p536

Calls for fuller investigation as national hero confesses.

David Cyranoski and Erika Check


Antarctic ice puts climate predictions to the test p536

Frozen record of the past reveals models' shortcomings.

Michael Hopkin


Titan: tapping the flood of data p538

The first analyses of the Huygens mission to Titan are published this week. Mark Peplow charts the satellite's transition from fogbound moon to familiar landscape, and finds out why scientists long to return.


Rocky future predicted for labs that rely on postdocs p541

Dependence on foreign expertise threatens US research.

Geoff Brumfiel


Sidelines p541


Europe's cash crisis puts space plans under threat p542

ESA budget review puts mission to Mercury in jeopardy

Jenny Hogan


Hayabusa ready to head home with asteroid sample p542

Concern over engine damage mars celebrations.

Ichiko Fuyuno


News in brief p544



News Features

Science in the web age: The expanding electronic universe p547


See also: Editor's summary

Science in the web age: Joint efforts p548

At its best, academia is a marketplace of ideas. But many scientists are reluctant to embrace the latest web tools that would allow them to communicate their ideas in new ways, says Declan Butler.


Science in the web age: The real death of print p550

Despite clashes with publishers over copyright, Google's plan to make millions of books available online is turning the tide for efforts to digitize the world's literature. Andreas von Bubnoff tracks the demise of the printed page.


Science in the web age: Start your engines p554

Google has launched another challenge to commercial search services — this time aimed at scientists. But is the new engine running as smoothly as its fans hope? Jim Giles investigates.




Swiss star finds it tough at the top p557

Serono is calling in outside advice. Colin Macilwain investigates the future of Europe's leading biotech firm.




Automated grading of research performance clearly fails to measure up p559

N. Haeffner-Cavaillon, C. Graillot-Gak and C. Bréchot


Animal-rights zealots put wildlife welfare at risk p559

Peter B. Banks


Evaluation bias hits women who aren't twice as good p559

Marlene Zuk and Gunilla Rosenqvist



Books and Arts

Different class p561

The 'big three' universities in the United States are upholding a long tradition of élitism.

John Aubrey Douglass reviews The Chosen: The Hidden History of Admissions and Exclusion at Harvard, Yale, and Princeton


Cultural reflections p562

Howard P. Segal reviews Hubris and Hybrids: A Cultural History of Technology and Science


An inside view of the Universe p563

Shawn Cruzen reviews Theaters of Time and Space: American Planetaria, 1930–1970


Science in culture: Dying for a drink p564

Evolution goes backwards in the latest Guinness advertisement.

Martin Kemp



News and Views

Oceanography: The Atlantic heat conveyor slows p565

Computer simulations predict that global warming will weaken the ocean circulation that transports heat from the tropics to higher latitudes in the North Atlantic. Such an effect has now been detected.

Detlef Quadfasel


See also: Editor's summary

Biophysics: Assembly line inspection p566

Many of the biochemical events that occur in a cell are performed by huge complexes of proteins and nucleic acids. A cunning approach promises to show how the components convene to make a functioning 'machine'.

Sarah A. Woodson


See also: Editor's summary

50 & 100 years ago p567


Cell biology: A greasy grip p569

How do the lipids and proteins of the cell membrane interact to create a functioning barrier for the cell? A high-resolution structure of a membrane protein reveals intimate contacts with its lipid neighbours.

Anthony G. Lee


See also: Editor's summary

Planetary science: Clays in the history of Mars p570

The stream of revelations from Mars continues. The latest news — the discovery of clays in ancient terrains — helps to fill in the picture of the past existence of liquid water on the planet's surface.

Horton Newsom


See also: Editor's summary

Cell biology: Protein choreography p571

Just under the cell surface, proteins engage in an intricate ballet to drive a transport process called endocytosis. Much is known about the individual dancers, but now the choreography is revealed.

Mara C. Duncan and Gregory S. Payne


Correction p573



Brief Communications

Fruit bats as reservoirs of Ebola virus p575

Bat species eaten by people in central Africa show evidence of symptomless Ebola infection.

Eric M. Leroy, Brice Kumulungui, Xavier Pourrut, Pierre Rouquet, Alexandre Hassanin, Philippe Yaba, André Délicat, Janusz T. Paweska, Jean-Paul Gonzalez and Robert Swanepoel


See also: Editor's summary

Palaeoecology: A gigantic fossil arthropod trackway p576

Martin A. Whyte


See also: Editor's summary


Brief Communications Arising

Geochronology: Age of Mexican ash with alleged 'footprints' pE7

Paul R. Renne, Joshua M. Feinberg, Michael R. Waters, Joaquin Arroyo-Cabrales, Patricia Ochoa-Castillo, Mario Perez-Campa and Kim B. Knight


See also: Editor's summary


Insight: Membrane biology

Insight: Membrane biology

Membrane biology p577

Deepa Nath


Membranes are more mosaic than fluid p578

Donald M. Engelman


Solving the membrane protein folding problem p581

James U. Bowie


Membrane curvature and mechanisms of dynamic cell membrane remodelling p590

Harvey T. McMahon and Jennifer L. Gallop


Organelle identity and the signposts for membrane traffic p597

Rudy Behnia and Sean Munro


Plasma membrane phosphoinositide organization by protein electrostatics p605

Stuart McLaughlin and Diana Murray


Role of cholesterol and lipid organization in disease p612

Frederick R. Maxfield and Ira Tabas




Phyllosilicates on Mars and implications for early martian climate p623

F. Poulet, J.-P. Bibring, J. F. Mustard, A. Gendrin, N. Mangold, Y. Langevin, R. E. Arvidson, B. Gondet and C. Gomez and The Omega Team


See also: Editor's summary | News and Views by Newsom

An assembly landscape for the 30S ribosomal subunit p628

Megan W. T. Talkington, Gary Siuzdak and James R. Williamson


See also: Editor's summary | News and Views by Woodson

Lipid–protein interactions in double-layered two-dimensional AQP0 crystals p633

Tamir Gonen, Yifan Cheng, Piotr Sliz, Yoko Hiroaki, Yoshinori Fujiyoshi, Stephen C. Harrison and Thomas Walz


See also: Editor's summary | News and Views by Lee



Creation of a six-atom 'Schrödinger cat' state p639

D. Leibfried, E. Knill, S. Seidelin, J. Britton, R. B. Blakestad, J. Chiaverini, D. B. Hume, W. M. Itano, J. D. Jost, C. Langer, R. Ozeri, R. Reichle and D. J. Wineland


See also: Editor's summary

Scalable multiparticle entanglement of trapped ions p643

H. Häffner, W. Hänsel, C. F. Roos, J. Benhelm, D. Chek-al-kar, M. Chwalla, T. Körber, U. D. Rapol, M. Riebe, P. O. Schmidt, C. Becher, O. Gühne, W. Dür and R. Blatt


See also: Editor's summary

Origin of the metallic properties of heavily boron-doped superconducting diamond p647

T. Yokoya, T. Nakamura, T. Matsushita, T. Muro, Y. Takano, M. Nagao, T. Takenouchi, H. Kawarada and T. Oguchi


See also: Editor's summary

Chemically tailorable colloidal particles from infinite coordination polymers p651

Moonhyun Oh and Chad A. Mirkin


See also: Editor's summary

Slowing of the Atlantic meridional overturning circulation at 25° N p655

Harry L. Bryden, Hannah R. Longworth and Stuart A. Cunningham


See also: Editor's summary | News and Views by Quadfasel

Density dependence explains tree species abundance and diversity in tropical forests p658

Igor Volkov, Jayanth R. Banavar, Fangliang He, Stephen P. Hubbell and Amos Maritan


Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice p662

Iiris Hovatta, Richard S. Tennant, Robert Helton, Robert A. Marr, Oded Singer, Jeffrey M. Redwine, Julie A. Ellison, Eric E. Schadt, Inder M. Verma, David J. Lockhart and Carrolee Barlow


See also: Editor's summary

Risk of severe asthma episodes predicted from fluctuation analysis of airway function p667

Urs Frey, Tanja Brodbeck, Arnab Majumdar, D. Robin Taylor, G. Ian Town, Michael Silverman and Béla Suki


See also: Editor's summary

The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development p671

Eran Hornstein, Jennifer H. Mansfield, Soraya Yekta, Jimmy Kuang-Hsien Hu, Brian D. Harfe, Michael T. McManus, Scott Baskerville, David P. Bartel and Clifford J. Tabin


See also: Editor's summary

Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission p675

Jennifer L. Gallop, P. Jonathan G. Butler and Harvey T. McMahon


Global analysis of protein phosphorylation in yeast p679

Jason Ptacek, Geeta Devgan, Gregory Michaud, Heng Zhu, Xiaowei Zhu, Joseph Fasolo, Hong Guo, Ghil Jona, Ashton Breitkreutz, Richelle Sopko, Rhonda R. McCartney, Martin C. Schmidt, Najma Rachidi, Soo-Jung Lee, Angie S. Mah, Lihao Meng, Michael J. R. Stark, David F. Stern, Claudio De Virgilio, Mike Tyers, Brenda Andrews, Mark Gerstein, Barry Schweitzer, Paul F. Predki and Michael Snyder


See also: Editor's summary

Silencing of microRNAs in vivo with 'antagomirs' p685

Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich, Kallanthottathil G. Rajeev, Thomas Tuschl, Muthiah Manoharan and Markus Stoffel


See also: Editor's summary

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression p690

Andrew S. Turnell, Grant S. Stewart, Roger J. A. Grand, Susan M. Rookes, Ashley Martin, Hiroyuki Yamano, Stephen J. Elledge and Phillip H. Gallimore


Erratum: Astronomical pacing of methane release in the Early Jurassic period p696

David B. Kemp, Angela L. Coe, Anthony S. Cohen and Lorenz Schwark


Corrigendum: A network-based analysis of systemic inflammation in humans p696

Steve E. Calvano, Wenzhong Xiao, Daniel R. Richards, Ramon M. Felciano, Henry V. Baker, Raymond J. Cho, Richard O. Chen, Bernard H. Brownstein, J. Perren Cobb, S. Kevin Tschoeke, Carol Miller-Graziano, Lyle L. Moldawer, Michael N. Mindrinos, Ronald W. Davis, Ronald G. Tompkins and Stephen F. Lowry and The Inflammation and Host Response to Injury Large Scale Collaborative Research Program


Corrigendum: DNA sequence and analysis of human chromosome 18 p696

Chad Nusbaum, Michael C. Zody, Mark L. Borowsky, Michael Kamal, Chinnappa D. Kodira, Todd D. Taylor, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Amr Abouelleil, Nicole R. Allen, Scott Anderson, Toby Bloom, Boris Bugalter, Jonathan Butler, April Cook, David DeCaprio, Reinhard Engels, Manuel Garber, Andreas Gnirke, Nabil Hafez, Jennifer L. Hall, Catherine Hosage Norman, Takehiko Itoh, David B. Jaffe, Yoko Kuroki, Jessica Lehoczky, Annie Lui, Pendexter Macdonald, Evan Mauceli, Tarjei S. Mikkelsen, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Hideki Noguchi, Sinéad B. O'Leary, Keith O'Neill, Bruno Piqani, Cherylyn L. Smith, Jessica A. Talamas, Kerri Topham, Yasushi Totoki, Atsushi Toyoda, Hester M. Wain, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Asao Fujiyama, Masahira Hattori, Bruce W. Birren, Yoshiyuki Sakaki and Eric S. Lander



Technology Features

Cell biology: Ion channels and stem cells p699

Ion channels, stem cells and cell signalling are the focus of intense interest in both cell biology and drug discovery. Pete Moore takes a look at what's on offer for the researcher.

Pete Moore


Cell biology: Maximizing return p699


Cell biology: Stem-cell options p700


Cell biology: Banking on stem cells p701


Cell biology: Signals of disease p702


Cell biology: Table of suppliers p703





Physics in crisis? p705

The falling number of physicists in England and Wales needs to be addressed.

Paul Smaglik


Careers and Recruitment

Thinking outside the cell p706

New tools and technologies are allowing cell biologists to take a more holistic view. To make the most of this, they are teaming up with scientists from other fields. Corie Lok reports.

Corie Lok



Highlight: The National Institutes of Health




The Albian message p710

A blast from the past.

Oliver Morton


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