Editor's Summary

1 December 2005

Kinases on the map

Protein phosphorylation is involved in the regulation of many basic cellular processes, so it is a prime target for analysis by proteomics. Proteome chip technology has now been used to produce a first-generation map of the global phosphorylation networks in yeast. More than 4,000 interactions were found for over 1,300 proteins, and substrates were identified for the majority of yeast kinases. Many of the yeast proteins and pathways are conserved in other eukaryotes, so this new resource will be of relevance to the mechanisms of protein phosphorylation in many other organisms. All of the data are freely available in a searchable format.

Letter: Global analysis of protein phosphorylation in yeast

Jason Ptacek, Geeta Devgan, Gregory Michaud, Heng Zhu, Xiaowei Zhu, Joseph Fasolo, Hong Guo, Ghil Jona, Ashton Breitkreutz, Richelle Sopko, Rhonda R. McCartney, Martin C. Schmidt, Najma Rachidi, Soo-Jung Lee, Angie S. Mah, Lihao Meng, Michael J. R. Stark, David F. Stern, Claudio De Virgilio, Mike Tyers, Brenda Andrews, Mark Gerstein, Barry Schweitzer, Paul F. Predki and Michael Snyder

doi:10.1038/nature04187

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