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Nature 438, 441-442 (23 November 2005) | doi:10.1038/nature04405;

Open Innovation Challenges

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Synthetic biology: Engineering Escherichia coli to see light

We have designed a bacterial system that is switched between different states by red light. The system consists of a synthetic sensor kinase that allows a lawn of bacteria to function as a biological film, such that the projection of a pattern of light on to the bacteria produces a high-definition (about 100 megapixels per square inch), two-dimensional chemical image.

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